Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration
المؤلفون المشاركون
Kamada, Hideki
Aritomo, Yuuichi
Ono, Masahiro
Masaki, Tsutomu
Kato, Kiyohito
Fujimori, Takayuki
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We review the utility of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA), a rapid, safe, cost-effective, and accurate diagnostic modality for evaluating pancreatic tumors.
EUS-FNA is currently used for the diagnosis and staging of pancreatic tumors.
The sensitivity of EUS-FNA for pancreatic malignancy ranges from 75% to 94%, and its specificity approaches 100% in most studies.
However, EUS-FNA has some limitations in the diagnosis of well-differentiated or early-stage cancers.
Recent evidence suggests that molecular biological analysis using specimens obtained by EUS-FNA improves diagnostic sensitivity and specificity, especially in borderline cytological cases.
It was also reported that additional information regarding patient response to chemotherapy, surgical resectability, time to metastasis, and overall survival was acquired from the genetic analysis of specimens obtained by EUS-FNA.
Other studies have revealed that the analysis of KRAS, MUC, p53, p16, S100P, SMAD4, and microRNAs is helpful in making the diagnosis of pancreatic carcinoma.
In this paper, we describe the present state of genetic diagnostic techniques for use with EUS-FNA samples in pancreatic diseases.
We also discuss the role of molecular biological analyses for the diagnosis of pancreatic carcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kato, Kiyohito& Kamada, Hideki& Fujimori, Takayuki& Aritomo, Yuuichi& Ono, Masahiro& Masaki, Tsutomu. 2012. Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456802
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kato, Kiyohito…[et al.]. Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration. Gastroenterology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-456802
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kato, Kiyohito& Kamada, Hideki& Fujimori, Takayuki& Aritomo, Yuuichi& Ono, Masahiro& Masaki, Tsutomu. Molecular Biologic Approach to the Diagnosis of Pancreatic Carcinoma Using Specimens Obtained by EUS-Guided Fine Needle Aspiration. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-456802
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456802
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر