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The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2M Phase by Binding to Cyclin D1
المؤلفون المشاركون
Khandelwal, Payal
Cox, John
Guntaka, Ramareddy V.
Padala, Mythili K.
المصدر
International Journal of Cell Biology
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-04-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Y-box binding protein YB-1 is a multifunctional protein involved in cell proliferation, regulation of transcription and translation.
Our previous study indicated that disruption of one allele of Chk-YB-1b gene in DT-40 cells resulted in major defects in the cell cycle.
The abnormalities seen in heterozygous mutants could be attributed to a dominant negative effect exerted by the disrupted YB-1 allele product.
To test this hypothesis the N-terminal sequence of the YB-1 was fused with the third helix of antennapedia and the green fluorescent protein.
These purified fusion proteins were introduced into rat hepatoma cells and their effect on cell proliferation was studied.
Results indicate that the N-terminal 77 amino acid domain of the YB-1 protein induced the cells to arrest in G2/M phase of the cell cycle and undergo apoptosis.
Additional deletion analysis indicated that as few as 26 amino acids of the N-terminus of YB-1 can cause these phenotypic changes.
We further demonstrated that this N-terminal 77 amino acid domain of YB-1 sequesters cyclin D1 in the cytoplasm of cells at G2/M phase of cell cycle.
We conclude that the N-terminal domain of YB-1 plays a major role in cell cycle progression through G2/M phase of cell cycle.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khandelwal, Payal& Padala, Mythili K.& Cox, John& Guntaka, Ramareddy V.. 2010. The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2M Phase by Binding to Cyclin D1. International Journal of Cell Biology،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-456803
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khandelwal, Payal…[et al.]. The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2M Phase by Binding to Cyclin D1. International Journal of Cell Biology No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-456803
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khandelwal, Payal& Padala, Mythili K.& Cox, John& Guntaka, Ramareddy V.. The N-Terminal Domain of Y-Box Binding Protein-1 Induces Cell Cycle Arrest in G2M Phase by Binding to Cyclin D1. International Journal of Cell Biology. 2010. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-456803
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456803
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