Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound Healing
المؤلفون المشاركون
Sinno, Hani
Jardin, Barbara
Prakash, Satya
Williams, Bruce
Watters, Kevin
Beckman, Lorne
Winocour, Sebastian
Brimo, Fadi
Philip, Anie
Malhotra, Meenakshi
Lutfy, Justyn
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-23
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Complements C3 and C5 have independently been shown to augment and increase wound healing and strength.
Our goal was to investigate the combinatorial effect of complements C3 and C5 on wound healing.
Methods.
Each rat served as its own control where topical collagen was applied to one incision and 100 nM of C3 and C5 in collagen vehicle was applied to the other incision (n=6).
To compare between systemic effects, a sham group of rats (n=6) was treated with collagen alone on one wound and saline on the other.
At day 3, the tissue was examined for maximal breaking strength (MBS) and sectioned for histological examination.
Results.
There was a statistically significant 88% increase in MBS with the topical application of C3C5 when compared to sham wounds (n<0.05).
This was correlated with increased fibroblast and collagen deposition in the treated wounds.
Furthermore, there appeared to be an additive hemostatic effect with the C3C5 combination.
Conclusions.
The combination of complements C3 and C5 as a topical application drug to skin wounds significantly increased wound healing maximum breaking strength as early as 3 days.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sinno, Hani& Malhotra, Meenakshi& Lutfy, Justyn& Jardin, Barbara& Winocour, Sebastian& Brimo, Fadi…[et al.]. 2013. Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound Healing. Plastic Surgery International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sinno, Hani…[et al.]. Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound Healing. Plastic Surgery International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-456838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sinno, Hani& Malhotra, Meenakshi& Lutfy, Justyn& Jardin, Barbara& Winocour, Sebastian& Brimo, Fadi…[et al.]. Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound Healing. Plastic Surgery International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-456838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر