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Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of MetPI3kAkt Pathway and Induction of Apoptosis
المؤلفون المشاركون
Wang, Li-fang
Cao, Fei
Kang, Xiao-Hong
Gong, Ya-Bin
Liao, Ming-juan
Xu, Ling
Wang, Zhong-Qi
Xu, Zhen-Ye
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, have shown promising therapeutic efficacy in nonsmall cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor- (EGFR-) activating mutation.
However, the inevitable recurrence resulting from acquired resistance has limited the clinical improvement in therapy outcomes.
Many studies demonstrate that hepatocyte growth factor- (HGF-) Met axis plays an important role in tumor progression and drug sensitivity.
HGF may induce resistance to EGFR-TKIs in EGFR mutant lung cancer cells by Met/PI3K/Akt signaling.
The purpose of this study was to determine whether bufalin, a major bioactive component of Venenum Bufonis, could reverse HGF-induced resistance to reversible and irreversible EGFR-TKIs in mutant lung cancer cells PC-9, HCC827, and H1975.
Our studies showed that bufalin could reverse resistance to reversible and irreversible EGFR-TKIs induced by exogenous HGF in EGFR mutant lung cancer cells by inhibiting the Met/PI3K/Akt pathway and inducing death signaling.
These results suggested that bufalin might have a potential to overcome HGF-induced resistance to molecular-targeted drugs for lung cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Xiao-Hong& Xu, Zhen-Ye& Gong, Ya-Bin& Wang, Li-fang& Wang, Zhong-Qi& Xu, Ling…[et al.]. 2013. Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of MetPI3kAkt Pathway and Induction of Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456839
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Xiao-Hong…[et al.]. Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of MetPI3kAkt Pathway and Induction of Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-456839
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Xiao-Hong& Xu, Zhen-Ye& Gong, Ya-Bin& Wang, Li-fang& Wang, Zhong-Qi& Xu, Ling…[et al.]. Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of MetPI3kAkt Pathway and Induction of Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-456839
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456839
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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