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Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses : Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas
المؤلفون المشاركون
Hjelme, Dag R.
Östling, Dan
Spigset, Olav
Aadahl, Petter
Skjaervold, Nils K.
Lyng, Oddveig
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-27
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The aim of this study was to construct a glucose regulatory algorithm by employing the natural pulsatile pattern of insulin secretion and the oscillatory pattern of resting blood glucose levels and further to regulate the blood glucose level in diabetic pigs by this method.
We developed a control algorithm based on repetitive intravenous bolus injections of insulin and combined this with an intravascular blood glucose monitor.
Four anesthetized pigs were used in the study.
The animals developed a mildly diabetic state from streptozotocin pretreatment.
They were steadily brought within the blood glucose target range of 4.5–6.0 mmol/L in 21 to 121 min and kept within that range for 128 to 238 min (hypoglycemic values varied from 2.9 to 51.1 min).
The study confirmed our hypotheses regarding the feasibility of this new principle for blood glucose control, and the algorithm was constantly improved during the study to produce the best results in the last animals.
The main obstacles were the drift of the IvS-1 sensor and problems with the calibration procedure, which calls for an improvement in the sensor stability before this method can be applied fully in new studies in animals and humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Skjaervold, Nils K.& Östling, Dan& Hjelme, Dag R.& Spigset, Olav& Lyng, Oddveig& Aadahl, Petter. 2013. Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses : Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456865
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Skjaervold, Nils K.…[et al.]. Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses : Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456865
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Skjaervold, Nils K.& Östling, Dan& Hjelme, Dag R.& Spigset, Olav& Lyng, Oddveig& Aadahl, Petter. Blood Glucose Control Using a Novel Continuous Blood Glucose Monitor and Repetitive Intravenous Insulin Boluses : Exploiting Natural Insulin Pulsatility as a Principle for a Future Artificial Pancreas. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456865
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456865
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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