Prognostic Significance of Vascular Endothelial Growth Factor Serum Determination in Women with Ovarian Cancer
المؤلفون المشاركون
Pecorelli, Sergio
Ravaggi, Antonella
Franceschini, Roberta
Specchia, Claudia
Gion, Massimo
Bignotti, Eliana
Bandiera, Elisabetta
Santin, Alessandro Davide
Trevisiol, Chiara
المصدر
ISRN Obstetrics and Gynecology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-26
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
We performed a review of the literature to elucidate the potential prognostic significance of serum vascular endothelial growth factor (sVEGF) levels in ovarian cancer.
Methods.
Eligible studies in English and Italian were identified in MEDLINE/PubMed from VEGF discovery to October 2011.
All studies evaluating: (i) sVEGF levels before any surgical and chemotherapeutic treatment; (ii) the association between sVEGF levels and the established prognostic variables; (iii) the value of sVEGF levels in predicting patients’ outcomes, were selected for this review.
Results.
The search resulted in 758 titles.
Nine studies met the inclusion criteria.
A statistically significant association between the level of sVEGF and FIGO stage, tumour grade, residual tumour size, lymph node involvement, and presence of ascites was found in at least one study.
sVEGF, in comparison with the established prognostic factors, appears to be the best prognostic marker for overall survival, since it stands out as an independent prognostic factor in most of the studies considered.
Moreover, sVEGF levels were shown to be independent prognostic factors by 2 out of the 3 studies that considered DFS as an end point.
Conclusion.
High levels of sVEGF identify a subgroup of patients with higher risk of death and/or recurrence.
These patients should be eligible for individually tailored therapeutic interventions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bandiera, Elisabetta& Franceschini, Roberta& Specchia, Claudia& Bignotti, Eliana& Trevisiol, Chiara& Gion, Massimo…[et al.]. 2012. Prognostic Significance of Vascular Endothelial Growth Factor Serum Determination in Women with Ovarian Cancer. ISRN Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-456935
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bandiera, Elisabetta…[et al.]. Prognostic Significance of Vascular Endothelial Growth Factor Serum Determination in Women with Ovarian Cancer. ISRN Obstetrics and Gynecology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-456935
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bandiera, Elisabetta& Franceschini, Roberta& Specchia, Claudia& Bignotti, Eliana& Trevisiol, Chiara& Gion, Massimo…[et al.]. Prognostic Significance of Vascular Endothelial Growth Factor Serum Determination in Women with Ovarian Cancer. ISRN Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-456935
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456935
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر