Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia
المؤلفون المشاركون
Giles, Michelle
Nolan, David
Sirisanthana, Thira
Hoy, Jennifer
Amin, Janaki
Tanuma, Junko
Achhra, Amit C.
Parwati Merati, Tuti
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We explored the mean differences in routinely measured lipids (total cholesterol, triglycerides, and high-density lipoprotein cholesterol) according to exposure to different combination antiretroviral regimens in Asian (n=2051) and Australian (predominantly Caucasian, n=794) cohorts.
The regimen was defined as at least 3 antiretroviral drugs with at least 2 nucleoside-reverse transcriptases (NRTIs) and either of at least one protease inhibitor (PI) or non-nucleoside-reverse transcriptases (NNRTIs).
We categorised cART regimens as: NRTIs as tenofovir based or not; NNRTIs as nevirapine or efavirenz (but not both); and PI as atazanavir based or not.
We found that the impact of various antiretroviral regimens on lipids in Asian and Australian cohorts was only different by cohort for total cholesterol (P for interaction between regimen and cohort: <0.001) but not in case of other lipids (P for interaction: >0.05).
The differences in total cholesterol were however small and unlikely to be of clinical significance.
Overall, tenofovir with nevirapine or atazanavir was associated with the most favorable lipids, while the PI regimens without tenofovir and atazanavir were associated with least favorable lipids.
We conclude that the impact of various ART regimens on lipids is largely similar in Asian and Australian cohorts and that the newer drugs such as tenofovir and atazanavir are likely to provide similar benefit in terms of lipid profiles in both populations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Achhra, Amit C.& Amin, Janaki& Hoy, Jennifer& Tanuma, Junko& Sirisanthana, Thira& Nolan, David…[et al.]. 2012. Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Achhra, Amit C.…[et al.]. Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia. AIDS Research and Treatment No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-456990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Achhra, Amit C.& Amin, Janaki& Hoy, Jennifer& Tanuma, Junko& Sirisanthana, Thira& Nolan, David…[et al.]. Differences in Lipid Measurements by Antiretroviral Regimen Exposure in Cohorts from Asia and Australia. AIDS Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-456990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-456990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر