Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis
المؤلفون المشاركون
Banks, Peter A.
Sainani, Nisha I.
Bellizzi, Andrew M.
Conwell, Darwin L.
Lee, Linda S.
Paulo, Joao A.
Suleiman, Shadeah
Kadiyala, Vivek
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Differentiating branch duct from mixed intraductal papillary mucinous neoplasm (BD-IPMN) is problematic, but clinically important as mixed IPMNs are managed surgically, while some BD-IPMN may be followed.
Inflammatory mediator proteins (IMPs) have been implicated in acute and chronic inflammatory and malignant pancreatic diseases.
Aim.
To compare IMP profile of pancreatic cyst fluid collected endoscopically from BD-IPMN and mixed IPMN.
Methods.
Pancreatic cyst fluid from ten patients (5 BD-IPMN and 5 mixed IPMN) was collected by endoscopic ultrasound-guided fine needle aspiration or endoscopic retrograde cholangiopancreatography.
Concentrations of 89 IMPs in these samples were determined using a multiplexed bead-based microarray protein assay and compared between BD-IPMN and mixed IPMN.
Results.
Eighty-six of 89 IMPs were detected in at least one of the 10 samples.
Fourteen IMPs were detected only in mixed IPMN, while none were only in BD-IPMN.
Of these, TGF-β1 was most prevalent, present in 3 of 5 mixed IPMNs.
Seventy-two IMPs were detected in both BD-IPMN and mixed IPMNs.
Of these, only G-CSF (P<0.05) was present in higher concentrations in mixed IPMNs.
Conclusion.
TGF-β1 and G-CSF detected in endoscopically collected pancreatic cyst fluid are potential diagnostic biomarkers capable of distinguishing mixed IPMN from BD-IPMN.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Linda S.& Bellizzi, Andrew M.& Banks, Peter A.& Sainani, Nisha I.& Kadiyala, Vivek& Suleiman, Shadeah…[et al.]. 2012. Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-457084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Linda S.…[et al.]. Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis. Gastroenterology Research and Practice No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-457084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Linda S.& Bellizzi, Andrew M.& Banks, Peter A.& Sainani, Nisha I.& Kadiyala, Vivek& Suleiman, Shadeah…[et al.]. Differentiating Branch Duct and Mixed IPMN in Endoscopically Collected Pancreatic Cyst Fluid via Cytokine Analysis. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-457084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر