Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users : A Study with the General Practice Research Database
المؤلفون المشاركون
Shatapathy, Chetan C.
Brunner, Elizabeth
Jones, Meghan E.
van Staa, Tjeerd P.
Motsko, Stephen
Patel, Deven
Murray-Thomas, Tarita
المصدر
Cardiovascular Psychiatry and Neurology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Objective.
Antipsychotics have been associated with increased cardiac events including mortality.
This study assessed cardiac events including mortality among antipsychotic users relative to nonusers.
Methods.
The General Practice Research Database (GPRD) was used to identify antipsychotic users, matched general population controls, and psychiatric diseased nonusers.
Outcomes included cardiac mortality, sudden cardiac death (SCD), all-cause mortality (excluding suicide), coronary heart disease (CHD), and ventricular arrhythmias (VA).
Sensitivity analyses were conducted for age, dose, duration, antipsychotic type, and psychiatric disease.
Results.
183,392 antipsychotic users (115,491 typical and 67,901 atypical), 544,726 general population controls, and 193,920 psychiatric nonusers were identified.
Nonusers with schizophrenia, dementia, or bipolar disorder had increased risks of all-cause mortality compared to general population controls, while nonusers with major depression had comparable risks.
Relative to psychiatric nonusers, the adjusted relative ratios (aRR) of all-cause mortality in antipsychotic users was 1.75 (95% CI: 1.64–1.87); cardiac mortality 1.72 (95% CI: 1.42–2.07); SCD primary definition 5.76 (95% CI: 2.90–11.45); SCD secondary definition 2.15 (95% CI: 1.64–2.81); CHD 1.16 (95% CI: 0.94–1.44); and VA 1.16 (95% CI: 1.02–1.31).
aRRs of the various outcomes were lower for atypical versus typical antipsychotics (all-cause mortality 0.83 (95% CI: 0.80–0.85); cardiac mortality 0.89 (95% CI: 0.82–0.97); and SCD secondary definition 0.76 (95% CI: 0.55–1.04).
Conclusions.
Antipsychotic users had an increased risk of cardiac mortality, all-cause mortality, and SCD compared to a psychiatric nonuser cohort.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Murray-Thomas, Tarita& Jones, Meghan E.& Patel, Deven& Brunner, Elizabeth& Shatapathy, Chetan C.& Motsko, Stephen…[et al.]. 2013. Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users : A Study with the General Practice Research Database. Cardiovascular Psychiatry and Neurology،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-457108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Murray-Thomas, Tarita…[et al.]. Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users : A Study with the General Practice Research Database. Cardiovascular Psychiatry and Neurology No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-457108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Murray-Thomas, Tarita& Jones, Meghan E.& Patel, Deven& Brunner, Elizabeth& Shatapathy, Chetan C.& Motsko, Stephen…[et al.]. Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users : A Study with the General Practice Research Database. Cardiovascular Psychiatry and Neurology. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-457108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر