Antibacterial and Antioxidant Activities of Derriobtusone A Isolated from Lonchocarpus obtusus

المؤلفون المشاركون

Albuquerque, Maria Rose Jane Ribeiro
Pessoa, Otília Deusdênia Loiola
Arruda, Francisco Vassiliepe Sousa
dos Santos, Hélcio Silva
Vasconcelos, Mayron Alves
Henriques, Mariana
Cavada, Benildo Sousa
Saker-Sampaio, Silvana
de Alencar, Daniel Barroso
Teixeira, Edson Holanda
Pereira, Maria Olivia
Bandeira, Paulo Nogueira

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-06-01

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

This study evaluated the effect of derriobtusone A, a flavonoid isolated from Lonchocarpus obtusus, on two important pathogenic bacteria, Staphylococcus aureus and Escherichia coli, as well as its antioxidant activity and toxicity.

Planktonic growth assays were performed, and the inhibition of biofilm formation was evaluated.

In addition, antioxidant activity was assessed by DPPH radical scavenging assay, ferrous ion chelating assay, ferric-reducing antioxidant power assay, and β-carotene bleaching assay.

Toxicity was evaluated by the brine shrimp lethality test.

Results showed that derriobtusone A completely inhibited the planktonic growth of S.

aureus at 250 and 500 μg/mL; however, it did not have the same activity on E.

coli.

Derriobtusone A reduced the biomass and colony-forming unit (cfu) of S.

aureus biofilm at concentrations of 250 and 500 μg/mL.

In various concentrations, it reduced the biofilm biomass of E.

coli, and, in all concentrations, it weakly reduced the cfu.

Derriobtusone A showed highly efficient antioxidant ability in scavenging DPPH radical and inhibiting β-carotene oxidation.

The compound showed no lethality to Artemia sp.

nauplii.

In conclusion, derriobtusone A may be an effective molecule against S.

aureus and its biofilm, as well as a potential antioxidant compound with no toxicity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Vasconcelos, Mayron Alves& Arruda, Francisco Vassiliepe Sousa& de Alencar, Daniel Barroso& Saker-Sampaio, Silvana& Albuquerque, Maria Rose Jane Ribeiro& dos Santos, Hélcio Silva…[et al.]. 2014. Antibacterial and Antioxidant Activities of Derriobtusone A Isolated from Lonchocarpus obtusus. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457223

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Vasconcelos, Mayron Alves…[et al.]. Antibacterial and Antioxidant Activities of Derriobtusone A Isolated from Lonchocarpus obtusus. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-457223

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Vasconcelos, Mayron Alves& Arruda, Francisco Vassiliepe Sousa& de Alencar, Daniel Barroso& Saker-Sampaio, Silvana& Albuquerque, Maria Rose Jane Ribeiro& dos Santos, Hélcio Silva…[et al.]. Antibacterial and Antioxidant Activities of Derriobtusone A Isolated from Lonchocarpus obtusus. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457223

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-457223