Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract : Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPaseH. pylori Inhibition and Anti-Oxidative Mechanism
المؤلفون المشاركون
Annaiah, Harish Nayaka Mysore
Dharmesh, Shylaja M.
Nanjundaiah, Siddaraju M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Zinger officinale has been used as a traditional source against gastric disturbances from time immemorial.
The ulcer-preventive properties of aqueous extract of ginger rhizome (GRAE) belonging to the family Zingiberaceae is reported in the present study.
GRAE at 200 mg kg−1 b.w.
protected up to 86% and 77% for the swim stress-/ethanol stress-induced ulcers with an ulcer index (UI) of 50 ± 4.0/46 ± 4.0, respectively, similar to that of lansoprazole (80%) at 30 mg kg−1 b.w.
Increased H+, K+-ATPase activity and thiobarbituric acid reactive substances (TBARS) were observed in ulcer-induced rats, while GRAE fed rats showed normalized levels and GRAE also normalized depleted/amplified anti-oxidant enzymes in swim stress and ethanol stress-induced animals.
Gastric mucin damage was recovered up to 77% and 74% in swim stress and ethanol stress, respectively after GRAE treatment.
GRAE also inhibited the growth of H.
pylori with MIC of 300 ± 38 μg and also possessed reducing power, free radical scavenging ability with an IC50 of 6.8 ± 0.4 μg mL−1 gallic acid equivalent (GAE).
DNA protection up to 90% at 0.4 μg was also observed.
Toxicity studies indicated no lethal effects in rats fed up to 5 g kg−1 b.w.
Compositional analysis favored by determination of the efficacy of individual phenolic acids towards their potential ulcer-preventive ability revealed that between cinnamic (50%) and gallic (46%) phenolic acids, cinnamic acid appear to contribute to better H+, K+-ATPase and Helicobacter pylori inhibitory activity, while gallic acid contributes significantly to anti-oxidant activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nanjundaiah, Siddaraju M.& Annaiah, Harish Nayaka Mysore& Dharmesh, Shylaja M.. 2011. Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract : Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPaseH. pylori Inhibition and Anti-Oxidative Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-457299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nanjundaiah, Siddaraju M.…[et al.]. Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract : Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPaseH. pylori Inhibition and Anti-Oxidative Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-457299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nanjundaiah, Siddaraju M.& Annaiah, Harish Nayaka Mysore& Dharmesh, Shylaja M.. Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract : Role of Gallic Acid and Cinnamic Acid in H+, K+-ATPaseH. pylori Inhibition and Anti-Oxidative Mechanism. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-457299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر