Immunosuppressant-Associated Neurotoxicity Responding to Olanzapine

الملخص EN

Immunosuppressants, particularly tacrolimus, can induce neurotoxicity in solid organ transplantation cases.

A lower clinical threshold to switch from tacrolimus to another immunosuppressant agent has been a common approach to reverse this neurotoxicity.

However, immunosuppressant switch may place the graft at risk, and, in some cases, continuation of the same treatment protocol may be necessary.

We report a case of immunosuppressant-associated neurotoxicity with prominent neuropsychiatric manifestation and describe psychiatric intervention with olanzapine that led to clinical improvement while continuing tacrolimus maintenance.