Immunohistochemical Analysis of IL-6, IL-8CXCR2 Axis, Tyrp-STAT-3, and SOCS-3 in Lymph Nodes from Patients with Chronic Lymphocytic Leukemia : Correlation between Microvascular Characteristics and Prognostic Significance
المؤلفون المشاركون
Kavantzas, Nikolaos
Patsouris, Efstratios
Panayiotidis, Panayiotis P.
Moschogiannis, Maria
Siakantaris, Marina
Kokoris, Styliani
Tsirkinidis, Pantelis
Lakiotaki, Eleftheria
Levidou, Georgia
Pangalis, Gerassimos A.
Vassilakopoulos, Theodoros P.
Yiakoumis, Xanthi
Papadaki, Helen A.
Angelopoulou, Maria K.
Sepsa, Athanasia
Milionis, Vassilis
Kalpadakis, Christina
Sachanas, Sotirios
Korkolopoulou, Penelope
Kontopidou, Flora
Kyrtsonis, Marie-Christine
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-05
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A number of studies have looked into the pathophysiological role of angiogenesis in CLL, but the results have often been inconsistent.
We aimed to gain direct insight into the angiogenic process in lymph nodes involved by CLL, focusing on proangiogenic cytokines and microvessel morphometry.
The tissue levels of VEGF, Th-2 cytokines IL-6 and IL-8, IL-8 receptor CXCR2, and tyrosine p-STAT-3/SOCS-3 axis modulating cytokine expression were evaluated immunohistochemically in 62 CLL/SLL cases.
Microvascular characteristics were evaluated by image analysis.
Results were analyzed with regard to clinicopathological characteristics.
Proliferation centers (PCs) were less well vascularised compared to non-PC areas.
IL-8 and CXCR2 expression was distinctly uncommon as opposed to IL-6, VEGF and SOCS-3, which were detected in the vast majority of cases.
The latter two molecule expressions were more pronounced in the PCs in ∼40% of the cases.
p-STAT-3 immunoreactivity was recorded in 66.67% of the cases with a predilection for PCs.
Microvessel morphometry was unrelated to proangiogenic cytokines, p-STAT-3, SOCS-3, or survival.
Microvascular caliber and VEGF expression were higher in Binet stage A, whereasIL-6 expression was higher in stage C.
VEGF and p-STAT-3 exerted a favorable effect on progression, which remained significant in multivariate analysis, thereby constituting potential outcome predictors in CLL patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Levidou, Georgia& Sachanas, Sotirios& Pangalis, Gerassimos A.& Kalpadakis, Christina& Yiakoumis, Xanthi& Moschogiannis, Maria…[et al.]. 2014. Immunohistochemical Analysis of IL-6, IL-8CXCR2 Axis, Tyrp-STAT-3, and SOCS-3 in Lymph Nodes from Patients with Chronic Lymphocytic Leukemia : Correlation between Microvascular Characteristics and Prognostic Significance. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-457490
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Levidou, Georgia…[et al.]. Immunohistochemical Analysis of IL-6, IL-8CXCR2 Axis, Tyrp-STAT-3, and SOCS-3 in Lymph Nodes from Patients with Chronic Lymphocytic Leukemia : Correlation between Microvascular Characteristics and Prognostic Significance. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-457490
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Levidou, Georgia& Sachanas, Sotirios& Pangalis, Gerassimos A.& Kalpadakis, Christina& Yiakoumis, Xanthi& Moschogiannis, Maria…[et al.]. Immunohistochemical Analysis of IL-6, IL-8CXCR2 Axis, Tyrp-STAT-3, and SOCS-3 in Lymph Nodes from Patients with Chronic Lymphocytic Leukemia : Correlation between Microvascular Characteristics and Prognostic Significance. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-457490
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457490
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر