Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway
المؤلفون المشاركون
Lev-Ari, S.
Rimmon, A.
Vexler, A.
Earon, G.
Ron, I.
Berkovich, L.
المصدر
Biochemistry Research International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-27
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
There is an urgent need to develop new treatment strategies and drugs for pancreatic cancer that is highly resistant to radio-chemotherapy.
Aesculus hippocastanum (the horse chestnut) known in Chinese medicine as a plant with anti-inflammatory, antiedema, antianalgesic, and antipyretic activities.
The main active compound of this plant is Escin (C54H84O23).
Objective.
To evaluate the effect of Escin alone and combined with chemotherapy on pancreatic cancer cell survival and to unravel mechanism(s) of Escin anticancer activity.
Methods.
Cell survival was measured by XTT colorimetric assay.
Synergistic effect of combined therapy was determined by CalcuSyn software.
Cell cycle and induction of apoptosis were evaluated by FACS analysis.
Expression of NF-κB-related proteins (p65, IκBα, and p-IκBα) and cyclin D was evaluated by western blot analysis.
Results.
Escin decreased the survival of pancreatic cancer cells with IC50 = 10–20 M.
Escin combined with gemcitabine showed only additive effect, while its combination with cisplatin resulted in a significant synergistic cytotoxic effect in Panc-1 cells.
High concentrations of Escin induced apoptosis and decreased NF-κB-related proteins and cyclin D expression.
Conclusions.
Escin decreased pancreatic cancer cell survival, induced apoptosis, and downregulated NF-κB signaling pathway.
Moreover, Escin sensitized pancreatic cancer cells to chemotherapy.
Further translational research is required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rimmon, A.& Vexler, A.& Berkovich, L.& Earon, G.& Ron, I.& Lev-Ari, S.. 2013. Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway. Biochemistry Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-457533
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rimmon, A.…[et al.]. Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway. Biochemistry Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-457533
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rimmon, A.& Vexler, A.& Berkovich, L.& Earon, G.& Ron, I.& Lev-Ari, S.. Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway. Biochemistry Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-457533
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457533
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر