Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells

المؤلفون المشاركون

Mor, Eytan
Tzakis, Andreas G.
Weissbach, Tal
Meivar-Levy, Irit
Berneman, Dana
Ferber, Sarah
Ricordi, Camillo
Sapir, Tamar
Ravassard, Philippe
Polak-Charcon, Sylvie

المصدر

Journal of Transplantation

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-08-24

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الطب البشري

الملخص EN

Activation of the pancreatic lineage in the liver has been suggested as a potential autologous cell replacement therapy for diabetic patients.

Transcription factors-induced liver-to-pancreas reprogramming has been demonstrated in numerous species both in vivo and in vitro.

However, human-derived liver cells capable of acquiring the alternate pancreatic repertoire have never been characterized.

It is yet unknown whether hepatic-like stem cells or rather adult liver cells give rise to insulin-producing cells.

Using an in vitro experimental system, we demonstrate that proliferating adherent human liver cells acquire mesenchymal-like characteristics and a considerable level of cellular plasticity.

However, using a lineage-tracing approach, we demonstrate that insulin-producing cells are primarily generated in cells enriched for adult hepatic markers that coexpress both albumin and mesenchymal markers.

Taken together, our data suggest that adult human hepatic tissue retains a substantial level of developmental plasticity, which could be exploited in regenerative medicine approaches.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Meivar-Levy, Irit& Sapir, Tamar& Berneman, Dana& Weissbach, Tal& Polak-Charcon, Sylvie& Ravassard, Philippe…[et al.]. 2011. Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-457578

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Meivar-Levy, Irit…[et al.]. Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells. Journal of Transplantation No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-457578

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Meivar-Levy, Irit& Sapir, Tamar& Berneman, Dana& Weissbach, Tal& Polak-Charcon, Sylvie& Ravassard, Philippe…[et al.]. Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-457578

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-457578