Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network
المؤلفون المشاركون
Xue, Mengzhu
Zhang, Shoude
Liu, Xiaofeng
Li, Honglin
Zhang, Weidong
Shan, Lei
Cai, Chaoqian
Yu, Xiaojuan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
As the major issue to limit the use of drugs, drug safety leads to the attrition or failure in clinical trials of drugs.
Therefore, it would be more efficient to minimize therapeutic risks if it could be predicted before large-scale clinical trials.
Here, we integrated a network topology analysis with cheminformatics measurements on drug information from the DrugBank database to detect the discrepancies between approved drugs and withdrawn drugs and give drug safety indications.
Thus, 47 approved drugs were unfolded with higher similarity measurements to withdrawn ones by the same target and confirmed to be already withdrawn or discontinued in certain countries or regions in subsequent investigations.
Accordingly, with the 2D chemical fingerprint similarity calculation as a medium, the method was applied to predict pharmacovigilance for natural products from an in-house traditional Chinese medicine (TCM) database.
Among them, Silibinin was highlighted for the high similarity to the withdrawn drug Plicamycin although it was regarded as a promising drug candidate with a lower toxicity in existing reports.
In summary, the network approach integrated with cheminformatics could provide drug safety indications effectively, especially for compounds with unknown targets or mechanisms like natural products.
It would be helpful for drug safety surveillance in all phases of drug development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xue, Mengzhu& Zhang, Shoude& Cai, Chaoqian& Yu, Xiaojuan& Shan, Lei& Liu, Xiaofeng…[et al.]. 2013. Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-457892
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xue, Mengzhu…[et al.]. Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-457892
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xue, Mengzhu& Zhang, Shoude& Cai, Chaoqian& Yu, Xiaojuan& Shan, Lei& Liu, Xiaofeng…[et al.]. Predicting the Drug Safety for Traditional Chinese Medicine through a Comparative Analysis of Withdrawn Drugs Using Pharmacological Network. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-457892
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457892
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر