Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke
المؤلفون المشاركون
Chang, Ya-Ting
Chiang, Yi-Fang
Tsai, Nai-Wen
Lu, Cheng-Hsien
Huang, Chih-Cheng
Lin, Wei-Che
Lin, Yu-Jun
Huang, Chi-Ren
Chen, Shu-Fang
Chang, Wen-Neng
Cheng, Ben-Chung
Su, Chih-Min
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
This study investigated serum thiobarbituric acid-reactive substances (TBARS) and free thiol levels in different subtypes of acute ischemic stroke (AIS) and evaluated their association with clinical outcomes.
Methods.
This prospective study evaluated 100 AIS patients, including 75 with small-vessel and 25 with large-vessel diseases.
Serum oxidative stress (TBARS) and antioxidant (thiol) were determined within 48 hours and days 7 and 30 after stroke.
For comparison, 80 age- and sex-matched participants were evaluated as controls.
Results.
Serum TBARS was significantly higher and free thiol was lower in stroke patients than in the controls on days 1 and 7 after AIS.
The level of free thiol was significantly lower in the large-vessel disease than in the small-vessel disease on day 7 after stroke.
Using the stepwise logistic regression model for potential variables, only stroke subtype, NIHSS score, and serum TBARS level were independently associated with three-month outcome.
Higher TBARS and lower thiol levels in the acute phase of stroke were associated with poor outcome.
Conclusions.
Patients with large-vessel disease have higher oxidative stress but lower antioxidant defense compared to those with small-vessel disease after AIS.
Serum TBARS level at the acute phase of stroke is a potential predictor for three-month outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsai, Nai-Wen& Chang, Ya-Ting& Huang, Chi-Ren& Lin, Yu-Jun& Lin, Wei-Che& Cheng, Ben-Chung…[et al.]. 2014. Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-457906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsai, Nai-Wen…[et al.]. Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-457906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsai, Nai-Wen& Chang, Ya-Ting& Huang, Chi-Ren& Lin, Yu-Jun& Lin, Wei-Che& Cheng, Ben-Chung…[et al.]. Association between Oxidative Stress and Outcome in Different Subtypes of Acute Ischemic Stroke. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-457906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر