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Programmed Necrosis : A Prominent Mechanism of Cell Death following Neonatal Brain Injury
المؤلفون المشاركون
Northington, Frances J.
Chavez-Valdez, Raul
Martin, Lee J.
المصدر
Neurology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Despite the introduction of therapeutic hypothermia, neonatal hypoxic ischemic (HI) brain injury remains a common cause of developmental disability.
Development of rational adjuvant therapies to hypothermia requires understanding of the pathways of cell death and survival modulated by HI.
The conceptualization of the apoptosis-necrosis “continuum” in neonatal brain injury predicts mechanistic interactions between cell death and hydrid forms of cell death such as programmed or regulated necrosis.
Many of the components of the signaling pathway regulating programmed necrosis have been studied previously in models of neonatal HI.
In some of these investigations, they participate as part of the apoptotic pathways demonstrating clear overlap of programmed death pathways.
Receptor interacting protein (RIP)-1 is at the crossroads between types of cellular death and survival and RIP-1 kinase activity triggers formation of the necrosome (in complex with RIP-3) leading to programmed necrosis.
Neuroprotection afforded by the blockade of RIP-1 kinase following neonatal HI suggests a role for programmed necrosis in the HI injury to the developing brain.
Here, we briefly review the state of the knowledge about the mechanisms behind programmed necrosis in neonatal brain injury recognizing that a significant proportion of these data derive from experiments in cultured cell and some from in vivo adult animal models.
There are still more questions than answers, yet the fascinating new perspectives provided by the understanding of programmed necrosis in the developing brain may lay the foundation for new therapies for neonatal HI.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chavez-Valdez, Raul& Martin, Lee J.& Northington, Frances J.. 2012. Programmed Necrosis : A Prominent Mechanism of Cell Death following Neonatal Brain Injury. Neurology Research International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-457984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chavez-Valdez, Raul…[et al.]. Programmed Necrosis : A Prominent Mechanism of Cell Death following Neonatal Brain Injury. Neurology Research International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-457984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chavez-Valdez, Raul& Martin, Lee J.& Northington, Frances J.. Programmed Necrosis : A Prominent Mechanism of Cell Death following Neonatal Brain Injury. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-457984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-457984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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