Subacute Therapeutic Dosing of Artemether-Lumefantrine and Artesunate-Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats
المؤلفون المشاركون
Edewor, Gloria
Ekor, Martins
Otuechere, Chiagoziem A.
Kale, Oluwafemi Ezekiel
المصدر
Malaria Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Recent instances of breakdowns of malaria control programs and the constant emergence of drug-resistant parasites to monotherapies have shored up the use of artemisinin-based combination therapy (ACT) as the malaria therapy of choice.
We evaluated a subacute therapeutic dosing of artemether-lumefantrine and artesunate-amodiaquine on plasma cholesterol, renal antioxidants, and organ weights in rats.
Sixteen albino rats were grouped into three.
Group A (n=5) served as the control.
Groups B (n=6) and C (n=5) were administered, twice daily, oral therapeutic doses of artemether-lumefantrine (1.14/6.86 mg/kg/d) and artesunate-amodiaquine (2.86/8.58 mg/kg/d), respectively, for seven days.
From our results, ACTs did not significantly (P>0.05) alter catalase, superoxide dismutase, glutathione S-transferase, myeloperoxidase, and total glutathione levels when compared with the control.
Plasma total cholesterol levels also decreased insignificantly (P>0.05).
Organ-system weights were not significantly (P>0.05) different from control rats.
Artesunate-amodiaquine, but not artemether-lumefantrine, significantly increased (P<0.05) lactate dehydrogenase activity and also afforded a 27.2% decrease in heart weight when compared with control.
Also, both ACTs increased (P<0.05) lipid peroxidation.
Overall, artesunate-amodiaquine and artemether-lumefantrine may preserve renal antioxidants and organ weights in vivo.
However, caution is required above therapeutic indications or in chronic doses as this may predispose to renal oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Otuechere, Chiagoziem A.& Edewor, Gloria& Kale, Oluwafemi Ezekiel& Ekor, Martins. 2012. Subacute Therapeutic Dosing of Artemether-Lumefantrine and Artesunate-Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats. Malaria Research and Treatment،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-458032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Otuechere, Chiagoziem A.…[et al.]. Subacute Therapeutic Dosing of Artemether-Lumefantrine and Artesunate-Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats. Malaria Research and Treatment No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-458032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Otuechere, Chiagoziem A.& Edewor, Gloria& Kale, Oluwafemi Ezekiel& Ekor, Martins. Subacute Therapeutic Dosing of Artemether-Lumefantrine and Artesunate-Amodiaquine Combination Preserves Plasma Cholesterol, Renal Antioxidant Status, and Organ Weights in Rats. Malaria Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-458032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر