Hepatitis B Reactivation in a HBsAg-Negative, HBcAb-Positive Patient Receiving Fludarabine for the Treatment of Chronic Lymphocytic Leukaemia

المؤلفون المشاركون

De Leo, Pasqualina
Grasso, Alessandro
Malfatti, Federica
Toscanini, Federica
Calcagno, Giuseppe
Anselmo, Marco

المصدر

Case Reports in Hepatology

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-3، 3ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2011-07-10

دولة النشر

مصر

عدد الصفحات

3

التخصصات الرئيسية

الأمراض

الملخص EN

Hepatitis B virus (HBV) reactivation is an increasingly recognized cause of morbidity and mortality in patients undergoing chemotherapy.

In haematology, the risk of reactivation of B hepatitis among HBsAg-positive patients has been documented; therefore, use of lamivudine prophylaxis is recommended before starting chemotherapy.

Differently, for HBsAg-negative patients with markers of previous HBV infection (i.e., presence of isolated anti-HBc positivity) (anticore patients) management strategies are not univocal.

We describe a rare case of HBV reactivation in an anticore patient after fludarabine therapy for chronic lymphocytic leukaemia.

The patient fully recovered after a 6-month course of lamivudine with persistent HBV-DNA clearance and loss of HBsAg.

The most important feature of this case is that fludarabine alone infrequently determines HBV reactivation, especially in anticore patients.

Therefore, we suggest that patients candidates to receive fludarabine therapy should be considered for lamivudine prophylaxis, not only if HBsAg-positive, but even if anticore-positive only.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Toscanini, Federica& De Leo, Pasqualina& Calcagno, Giuseppe& Malfatti, Federica& Grasso, Alessandro& Anselmo, Marco. 2011. Hepatitis B Reactivation in a HBsAg-Negative, HBcAb-Positive Patient Receiving Fludarabine for the Treatment of Chronic Lymphocytic Leukaemia. Case Reports in Hepatology،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-458126

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Toscanini, Federica…[et al.]. Hepatitis B Reactivation in a HBsAg-Negative, HBcAb-Positive Patient Receiving Fludarabine for the Treatment of Chronic Lymphocytic Leukaemia. Case Reports in Hepatology No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-458126

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Toscanini, Federica& De Leo, Pasqualina& Calcagno, Giuseppe& Malfatti, Federica& Grasso, Alessandro& Anselmo, Marco. Hepatitis B Reactivation in a HBsAg-Negative, HBcAb-Positive Patient Receiving Fludarabine for the Treatment of Chronic Lymphocytic Leukaemia. Case Reports in Hepatology. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-458126

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-458126