Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles
المؤلفون المشاركون
Lin, Ta-Chen
Yang, Chien-Min
Chiang, Lien-Chai
Lin, Liang-Tzung
Lin, Chun-Ching
Cheng, Hua-Yew
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-05-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Phyllanthus urinaria Linnea (Euphorbiaceae) is one of the traditional medicinal plants widely used by oriental people to treat various diseases.
We have previously demonstrated that the acetone extract of P.
urinaria inhibits herpes simplex virus type 2 (HSV-2) but not HSV-1 infection.
In a continuing effort to clarify the antiviral mechanisms of P.
urinaria, we isolated the pure compound excoecarianin from the whole plant of P.
urinaria through acetone extraction, and investigated its anti-HSV-1 and HSV-2 activities.
Our results indicated that excoecarianin protected Vero cells from HSV-2 but not HSV-1 infection, and its 50% inhibitory concentration (IC50) was 1.4 ± 0.1 μM.
The antiviral effective concentration of excoecarianin did not affect the viability or the morphology of Vero cells.
Although excoecarianin inhibited HSV-2 infection, the inhibitory effect, however, was most prominent when excoecarianin was concurrently added with the virus.
Pretreatment of Vero cells with excoecarianin with removal of the drug prior to infection did not yield any antiviral effects, and the same observation was made for post viral entry treatment.
Subsequent studies revealed that excoecarianin inactivated HSV-2 virus particles to prevent viral infection.
A synergistic antiviral effect against HSV-2 was also observed when Vero cells were treated with a combination of acyclovir (ACV) and excoecarianin.
These results suggested that excoecarianin merits to be further explored as an entry inhibitor against HSV-2 and could potentially be investigated for combinatorial drug treatment with nucleoside analogues such as ACV in therapeutic management of HSV-2 infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Hua-Yew& Yang, Chien-Min& Lin, Ta-Chen& Lin, Liang-Tzung& Chiang, Lien-Chai& Lin, Chun-Ching. 2011. Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458148
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Hua-Yew…[et al.]. Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-458148
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Hua-Yew& Yang, Chien-Min& Lin, Ta-Chen& Lin, Liang-Tzung& Chiang, Lien-Chai& Lin, Chun-Ching. Excoecarianin, Isolated from Phyllanthus urinaria Linnea, Inhibits Herpes Simplex Virus Type 2 Infection through Inactivation of Viral Particles. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-458148
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458148
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر