![](/images/graphics-bg.png)
Green Tea Potentially Ameliorates Bisphenol A-Induced Oxidative Stress : An In Vitro and In Silico Study
المؤلفون المشاركون
Suthar, Hiral
Verma, R. J.
Patel, Saumya K.
Jasrai, Yogesh T.
المصدر
Biochemistry Research International
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The present investigation was an attempt to elucidate oxidative stress induced by bisphenol A on erythrocytes and its amelioration by green tea extract.
For this, venous blood samples from healthy human adults were collected in EDTA vials and used for preparation of erythrocytes suspension.
When erythrocyte suspensions were treated with different concentrations of BPA/H2O2, a dose-dependent increase in hemolysis occurred.
Similarly, when erythrocytes suspensions were treated with either different concentrations of H2O2 (0.05–0.25 mM) along with BPA (50 μg/mL) or 0.05 mM H2O2 along with different concentrations of BPA (50–250 μg/mL), dose-dependent significant increase in hemolysis occurred.
The effect of BPA and H2O2 was found to be additive.
For the confirmation, binding capacity of bisphenol A with erythrocyte proteins (hemoglobin, catalase, and glutathione peroxidase) was inspected using molecular docking tool, which showed presence of various hydrogen bonds of BPA with the proteins.
The present data clearly indicates that BPA causes oxidative stress in a similar way as H2O2 .
Concurrent addition of different concentrations (10–50 μg/mL) of green tea extract to reaction mixture containing high dose of bisphenol A (250 μg/mL) caused concentration-dependent amelioration in bisphenol A-induced hemolysis.
The effect was significant (P<0.05).
It is concluded that BPA-induced oxidative stress could be significantly mitigated by green tea extract.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Suthar, Hiral& Verma, R. J.& Patel, Saumya K.& Jasrai, Yogesh T.. 2014. Green Tea Potentially Ameliorates Bisphenol A-Induced Oxidative Stress : An In Vitro and In Silico Study. Biochemistry Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458223
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Suthar, Hiral…[et al.]. Green Tea Potentially Ameliorates Bisphenol A-Induced Oxidative Stress : An In Vitro and In Silico Study. Biochemistry Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-458223
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Suthar, Hiral& Verma, R. J.& Patel, Saumya K.& Jasrai, Yogesh T.. Green Tea Potentially Ameliorates Bisphenol A-Induced Oxidative Stress : An In Vitro and In Silico Study. Biochemistry Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-458223
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458223
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)