Synthesis of 6-(2-Methoxynaphthyl)‎-2,3-dihydro-1,2,4-triazine-3-thione as a New Reagent for Spectrophotometric Determination of Copper

الملخص EN

A simple, sensitive, accurate, and green spectrophotometric method for the determination of Cu(II) using newly synthesized reagent, 6-(2-methoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione (MNDTT), has been developed.

MNDTT was synthesized based on the acylation of methoxy naphthalene and reaction of the product with amyl nitrite, which upon reaction with thiosemicarbazide yielded 6-(2-meyhoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione.

MNDTT produces a dark red complex with copper in methanol according to the 1 : 2 stoichiometry.

Beer’s law was obeyed over the concentration range of 2.5–20 µg/mL with r2=0.992.

The limit of detection and limit of quantification were 0.33 and 1.10 µg/mL, respectively.

Within-day and between-day precision values were less than 3.68%.

Finally, the method has been applied to a dental alloy (110-plus) successfully and the results were compared with atomic absorption method.

The results showed that there was no significant difference between the two methods (P>0.05).