Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis

المؤلفون المشاركون

Knuefermann, Pascal
Duerr, Georg D.
Meyer, Rainer
Klein, Johanna
Schwederski, Markus
Torno, Alexandra
Hoeft, Andreas
Baumgarten, Georg
Boehm, Olaf
Lohner, Ralph
Narath, Carolin

المصدر

Mediators of Inflammation

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-07-02

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Aim was to elucidate the role of toll-like receptor 9 (TLR9) in cardiac inflammation and septic heart failure in a murine model of polymicrobial sepsis.

Methods.

Sepsis was induced via colon ascendens stent peritonitis (CASP) in C57BL/6 wild-type (WT) and TLR9-deficient (TLR9-D) mice.

Bacterial load in the peritoneal cavity and cardiac expression of inflammatory mediators were determined at 6, 12, 18, 24, and 36 h.

Eighteen hours after CASP cardiac function was monitored in vivo.

Sarcomere length of isolated cardiomyocytes was measured at 0.5 to 10 Hz after incubation with heat-inactivated bacteria.

Results.

CASP led to continuous release of bacteria into the peritoneal cavity, an increase of cytokines, and differential regulation of receptors of innate immunity in the heart.

Eighteen hours after CASP WT mice developed septic heart failure characterised by reduction of end-systolic pressure, stroke volume, cardiac output, and parameters of contractility.

This coincided with reduced cardiomyocyte sarcomere shortening.

TLR9 deficiency resulted in significant reduction of cardiac inflammation and a sustained heart function.

This was consistent with reduced mortality in TLR9-D compared to WT mice.

Conclusions.

In polymicrobial sepsis TLR9 signalling is pivotal to cardiac inflammation and septic heart failure.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lohner, Ralph& Schwederski, Markus& Narath, Carolin& Klein, Johanna& Duerr, Georg D.& Torno, Alexandra…[et al.]. 2013. Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-458322

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lohner, Ralph…[et al.]. Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis. Mediators of Inflammation No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-458322

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lohner, Ralph& Schwederski, Markus& Narath, Carolin& Klein, Johanna& Duerr, Georg D.& Torno, Alexandra…[et al.]. Toll-Like Receptor 9 Promotes Cardiac Inflammation and Heart Failure during Polymicrobial Sepsis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-458322

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-458322