Impact of Statins on Cognitive Deficits in Adult Male Rodents after Traumatic Brain Injury : A Systematic Review

المؤلفون المشاركون

Yang, Jingjing
Xiong, Xin-gui
Peng, Weijun
Yang, Bo
Wang, Lexing
Liang, Qinghua

المصدر

BioMed Research International

العدد

المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2014-07-23

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الطب البشري

الملخص EN

The efficacy of statin treatment on cognitive decline is controversial, and the effect of statins on cognitive deficits in individuals with traumatic brain injury (TBI) has yet to be investigated.

Therefore, we systematically reviewed the effect of statins on cognitive deficits in adult male rodents after TBI.

After identifying eligible studies by searching four electronic databases on February 28, 2014, we assessed study quality, evaluated the efficacy of statin treatment, and performed stratified metaregression and metaregression to assess the influence of study design on statin efficacy.

Eleven studies fulfilled our inclusion criteria from a total of 183 publications.

The overall methodological quality of these studies was poor.

Meta-analysis showed that statins exert statistically significant positive effects on cognitive performance after TBI.

Stratified analysis showed that atorvastatin has the greatest effect on acquisition memory, simvastatin has the greatest effect on retention memory, and statin effects on acquisition memory are higher in closed head injury models.

Metaregression analysis further showed that that animal species, study quality, and anesthetic agent impact statin effects on retention memory.

We conclude that statins might reduce cognitive deficits after TBI.

However, additional well-designed and well-reported animal studies are needed to inform further clinical study.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Peng, Weijun& Yang, Jingjing& Yang, Bo& Wang, Lexing& Xiong, Xin-gui& Liang, Qinghua. 2014. Impact of Statins on Cognitive Deficits in Adult Male Rodents after Traumatic Brain Injury : A Systematic Review. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-458355

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Peng, Weijun…[et al.]. Impact of Statins on Cognitive Deficits in Adult Male Rodents after Traumatic Brain Injury : A Systematic Review. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-458355

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Peng, Weijun& Yang, Jingjing& Yang, Bo& Wang, Lexing& Xiong, Xin-gui& Liang, Qinghua. Impact of Statins on Cognitive Deficits in Adult Male Rodents after Traumatic Brain Injury : A Systematic Review. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-458355

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-458355