MicroPETCT Imaging of [18F]-FEPPA in the Nonhuman Primate : A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity
المؤلفون المشاركون
Liu, Fang
Newport, Glenn D.
Callicott, Ralph
Apana, Scott M.
Paule, Merle G.
Zhang, Xuan
Wang, Cheng
Berridge, Marc S.
Liu, Shuliang
Slikker, William
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-05
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
The inhalation anesthetics nitrous oxide (N2O) and isoflurane (ISO) are used in surgical procedures for human infants.
Injury to the central nervous system is often accompanied by localization of activated microglia or astrocytosis at the site of injury.
The tracer that targets to the peripheral benzodiazepine receptor (PBR), [18F]N-2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([18F]-FEPPA), has been reported as a sensitive biomarker for the detection of neuronal damage/inflammation.
Methods.
On postnatal day (PND) 5 or 6 rhesus monkey neonates were exposed to a mixture of N2O/oxygen and ISO for 8 hours and control monkeys were exposed to room air.
MicroPET/CT images with [18F]-FEPPA were obtained for each monkey 1 day, one week, three weeks, and 6 months after the anesthetic exposure.
Results.
The radiotracer quickly distributed into the brains of both treated and control monkeys on all scan days.
One day after anesthetic exposure, the uptake of [18F]-FEPPA was significantly increased in the temporal lobe.
One week after exposure, the uptake of [18F]-FEPPA in the frontal lobe of treated animals was significantly greater than that in controls.
Conclusions.
These findings suggest that microPET imaging is capable of dynamic detection of inhaled anesthetic-induced brain damage in different brain regions of the nonhuman primate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Xuan& Paule, Merle G.& Newport, Glenn D.& Liu, Fang& Callicott, Ralph& Liu, Shuliang…[et al.]. 2012. MicroPETCT Imaging of [18F]-FEPPA in the Nonhuman Primate : A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity. ISRN Anesthesiology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458380
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Xuan…[et al.]. MicroPETCT Imaging of [18F]-FEPPA in the Nonhuman Primate : A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity. ISRN Anesthesiology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-458380
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Xuan& Paule, Merle G.& Newport, Glenn D.& Liu, Fang& Callicott, Ralph& Liu, Shuliang…[et al.]. MicroPETCT Imaging of [18F]-FEPPA in the Nonhuman Primate : A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity. ISRN Anesthesiology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458380
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458380
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر