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Alemtuzumab Plus Cyclosporine Treatment of the Autoimmune Hemolytic Anemia in an Adult Bowel Transplant
المؤلفون المشاركون
Giudice, V.
Finelli, C.
Pironi, L.
Morelli, Cristina
Stanzani, M.
Zanfi, C.
Pasqualini, E.
Ravaioli, M.
Pinna, Antonio Daniele
Di Simone, M.
Dazzi, Alessandro
Lauro, Augusto
المصدر
Case Reports in Transplantation
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-11
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
An adult male underwent a bowel transplant for tufting enteropathy, receiving alemtuzumab, tacrolimus, and steroids as immunosuppressants.
Five years later, he developed an autoimmune hemolytic anemia (AIHA), anti-IgG positive, with reduced reticulocyte count, leukopenia, and thrombocytopenia with antiplatelet antibodies.
After an unsuccessful initial treatment with high dose steroids, reduction in tacrolimus dose, and intravenous immunoglobulin (IVIG), a bone marrow biopsy revealed absence of erythroid maturation with precursor hyperplasia.
The patient was switched to sirolimus and received four doses of rituximab plus two courses of plasmapheresis, which decreased his transfusion requirements.
After a febrile episode one month later, the AIHA relapsed with corresponding decreases in platelet and leukocyte count: cyclosporine A (CsA) was started with a second course of rituximab and IVIG without response, even though repeat bone marrow biopsy did not reveal morphology correlated to an acquired pure red cell aplasia (APRCA).
Considering the similarity in his clinical and laboratory findings to APRCA, alemtuzumab was added (three doses over a week) with CsA followed by steroids.
The patient was eventually discharged transfusion-independent, with increasing hemoglobin (Hb) levels and normal platelet and leukocyte count.
One year later he is still disease-free with functioning graft.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lauro, Augusto& Stanzani, M.& Finelli, C.& Zanfi, C.& Morelli, Cristina& Pasqualini, E.…[et al.]. 2014. Alemtuzumab Plus Cyclosporine Treatment of the Autoimmune Hemolytic Anemia in an Adult Bowel Transplant. Case Reports in Transplantation،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-458498
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lauro, Augusto…[et al.]. Alemtuzumab Plus Cyclosporine Treatment of the Autoimmune Hemolytic Anemia in an Adult Bowel Transplant. Case Reports in Transplantation No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-458498
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lauro, Augusto& Stanzani, M.& Finelli, C.& Zanfi, C.& Morelli, Cristina& Pasqualini, E.…[et al.]. Alemtuzumab Plus Cyclosporine Treatment of the Autoimmune Hemolytic Anemia in an Adult Bowel Transplant. Case Reports in Transplantation. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-458498
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458498
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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