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Allopurinol, Benzbromarone, or a Combination in Treating Patients with Gout : Analysis of a Series of Outpatients
المؤلفون المشاركون
Carvalho, Mauricio
Buiar, Pedro Grachinski
Giovanella, Laura Helena
Severo, Carolina Rossetti
Azevedo, Valderilio Feijó
المصدر
International Journal of Rheumatology
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-12
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To profile a sample of gouty patients treated with allopurinol, benzbromarone, or a combination of these two drugs and to describe the impact of this therapy in reducing uric acid levels.
Methods.
An observational, transversal study was performed.
We evaluated 48 patients diagnosed with gout who were seen at the Outpatient Rheumatology Clinic of the Federal University of Paraná between January 2009 and November 2010.
Clinical data, creatinine serum levels, and basal and posttreatment levels of serum urates, transaminases, and bilirubins were recorded.
Uric acid levels were measured in a 24-hour urine sample.
Patients were divided into three groups: patients given only allopurinol (A), only benzbromarone (B), and both in combined therapy (A + B).
Results.
The average age of these patients was 56.6 ± 11.4 years, varying from 35 to 81 years.
The entire patient group experienced a significant drop in serum urate levels, from 8.5 ± 1.8 mg/dL (0.472 ± 0.1 mmol/L) to 6.7 ± 2.1 mg/dL (0.372 ± 0.116 mmol/L) (P<0.001), regardless of the prescribed medication.
The number of patients taking both drugs whose serum uric acid values fell within normal range (men <7 mg/dL (0.38 mmol/L) and women <6 mg/dL (0.33 mmol/L)) was 85.7% (6/7) while this value for the group taking benzbromarone alone was 75% (3/4) and for the group taking allopurinol alone this number was 51.8% (14/27).
Conclusions.
The therapeutic combination of benzbromarone and allopurinol significantly decreased serum urate levels in patients with gout when compared to individual use of each of these agents.
This finding is especially important in treating patients who cannot control hyperuricemia with monotherapy.
Benzbromarone alone or in combination with allopurinol has an important clinical role in controlling hyperuricemia in patients with gout.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azevedo, Valderilio Feijó& Buiar, Pedro Grachinski& Giovanella, Laura Helena& Severo, Carolina Rossetti& Carvalho, Mauricio. 2014. Allopurinol, Benzbromarone, or a Combination in Treating Patients with Gout : Analysis of a Series of Outpatients. International Journal of Rheumatology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-458559
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azevedo, Valderilio Feijó…[et al.]. Allopurinol, Benzbromarone, or a Combination in Treating Patients with Gout : Analysis of a Series of Outpatients. International Journal of Rheumatology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-458559
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azevedo, Valderilio Feijó& Buiar, Pedro Grachinski& Giovanella, Laura Helena& Severo, Carolina Rossetti& Carvalho, Mauricio. Allopurinol, Benzbromarone, or a Combination in Treating Patients with Gout : Analysis of a Series of Outpatients. International Journal of Rheumatology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-458559
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458559
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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