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Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology : Underlying Mechanisms and Potential Therapeutic Strategies
المؤلفون المشاركون
Walter, Dagmar
Milsom, Michael D.
Lier, Amelie
Geiselhart, Anja
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-23
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Fanconi anemia (FA) is the most common inherited bone marrow failure syndrome.
FA patients suffer to varying degrees from a heterogeneous range of developmental defects and, in addition, have an increased likelihood of developing cancer.
Almost all FA patients develop a severe, progressive bone marrow failure syndrome, which impacts upon the production of all hematopoietic lineages and, hence, is thought to be driven by a defect at the level of the hematopoietic stem cell (HSC).
This hypothesis would also correlate with the very high incidence of MDS and AML that is observed in FA patients.
In this paper, we discuss the evidence that supports the role of dysfunctional HSC biology in driving the etiology of the disease.
Furthermore, we consider the different model systems currently available to study the biology of cells defective in the FA signaling pathway and how they are informative in terms of identifying the physiologic mediators of HSC depletion and dissecting their putative mechanism of action.
Finally, we ask whether the insights gained using such disease models can be translated into potential novel therapeutic strategies for the treatment of the hematologic disorders in FA patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Geiselhart, Anja& Lier, Amelie& Walter, Dagmar& Milsom, Michael D.. 2012. Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology : Underlying Mechanisms and Potential Therapeutic Strategies. Anemia،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-458765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Geiselhart, Anja…[et al.]. Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology : Underlying Mechanisms and Potential Therapeutic Strategies. Anemia No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-458765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Geiselhart, Anja& Lier, Amelie& Walter, Dagmar& Milsom, Michael D.. Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology : Underlying Mechanisms and Potential Therapeutic Strategies. Anemia. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-458765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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