Modulation of Bacterial Pathogenesis by Oppressive Aging Factors : Insights into Host-Pneumococcal Interaction Strategies
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Streptococcus pneumonia, (Spn, the pneumococcus), is the leading cause of community-acquired pneumonia (CAP) and is responsible for 15–40% deaths in the elderly worldwide.
A primed inflammatory status is a significant risk factor for the increased severity of infectious diseases among the elderly (≥65 years of age).
Studies have shown that expression of host receptors that the pneumococci bind to invade the tissues are increased thereby increasing the susceptibility to pneumococcal challenge in aged mice.
Cellular senescence, an age-related phenomenon that leads to cell cycle arrest may also contribute to increased inflammation in aged mice.
Evidence of cellular senescence in aged lungs of humans and mice adds credits to the concept of inflammaging and enhanced bacterial ligands expression during aging.
Furthermore, cell senescence has been shown to occur in age-associated lung pathologies such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) that may predispose the elderly to pathogenic assaults, including S.
pneumoniae.
This review highlights the aspects of: chronic inflammation in the aged population; contribution of cellular senescence to age-associated inflammation and their impact on host receptor expression; and, increased susceptibility of fibrosis and emphysematous lesions-bearing lungs to microbial infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shivshankar, Pooja. 2012. Modulation of Bacterial Pathogenesis by Oppressive Aging Factors : Insights into Host-Pneumococcal Interaction Strategies. ISRN Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458787
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shivshankar, Pooja. Modulation of Bacterial Pathogenesis by Oppressive Aging Factors : Insights into Host-Pneumococcal Interaction Strategies. ISRN Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-458787
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shivshankar, Pooja. Modulation of Bacterial Pathogenesis by Oppressive Aging Factors : Insights into Host-Pneumococcal Interaction Strategies. ISRN Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-458787
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458787
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر