The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration : In Vitro Studies
المؤلفون المشاركون
Haastert-Talini, Kirsten
Shahar, Abraham
Margel, Shlomo
Levy, Itay
Fregnan, Federica
Grothe, Claudia
Ziv-Polat, Ofra
Geuna, Stefano
Neuman, Sara
Skaat, Hadas
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-15
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system.
The main disadvantage of the free growth factors is their short half-life of few minutes.
In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve growth factor (βNGF), glial cell-derived neurotrophic factor (GDNF), and basic fibroblast growth factor (FGF-2).
Comparative stability studies of free versus conjugated factors revealed that the conjugated neurotrophic factors were significantly more stable in tissue cultures and in medium at 37°C.
The biological effects of free versus conjugated neurotrophic factors were examined on organotypic dorsal root ganglion (DRG) cultures performed in NVR-Gel, composed mainly of hyaluronic acid and laminin.
Results revealed that the conjugated neurotrophic factors enhanced early nerve fiber sprouting compared to the corresponding free factors.
The most meaningful result was that conjugated-GDNF, accelerated the onset and progression of myelin significantly earlier than the free GDNF and the other free and conjugated factors.
This is probably due to the beneficial and long-acting effect that the stabilized conjugated-GDNF had on neurons and Schwann cells.
These conclusive results make NVR-Gel enriched with conjugated-GDNF, a desirable scaffold for the reconstruction of severed peripheral nerve.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ziv-Polat, Ofra& Shahar, Abraham& Levy, Itay& Skaat, Hadas& Neuman, Sara& Fregnan, Federica…[et al.]. 2014. The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration : In Vitro Studies. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-458861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ziv-Polat, Ofra…[et al.]. The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration : In Vitro Studies. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-458861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ziv-Polat, Ofra& Shahar, Abraham& Levy, Itay& Skaat, Hadas& Neuman, Sara& Fregnan, Federica…[et al.]. The Role of Neurotrophic Factors Conjugated to Iron Oxide Nanoparticles in Peripheral Nerve Regeneration : In Vitro Studies. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-458861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-458861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر