Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide

المؤلفون المشاركون

Davies, Henry
Yew, David Tai Wai
Han, Shu
Yang, Jing
Sun, Yayi
Zhang, Fan
Fang, Marong
Hu, Zhiying

المصدر

Mediators of Inflammation

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-24، 24ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-11-17

دولة النشر

مصر

عدد الصفحات

24

التخصصات الرئيسية

الأمراض

الملخص EN

Previous studies have shown that prevention of leukocyte infiltration by targeting integrins involved in transendothelial migration may suppress the clinical and pathological features of neuroinflammatory disease.

This study was designed to investigate the effects of C16, an ανβ3 integrin-binding peptide, in an acute experimental allergic encephalomyelitis (EAE) rat model.

Multiple histological and immunohistochemical staining, electron microscopy observation, ELISA assay, Western blot, and magnetic resonance imaging (MRI) were employed to assess the degree of inflammation, axonal loss, neuronal apoptosis, white matter demyelination, and extent of gliosis in the brain and spinal cord of differently treated EAE models.

The results showed that C16 treatment could inhibit extensive leukocyte and macrophage accumulation and infiltration and reduce cytokine tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) expression levels.

A significantly lower clinical score at the peak time of disease was also demonstrated in the C16 treated group.

Moreover, astrogliosis, demyelination, neuronal death, and axonal loss were all alleviated in C16 treated EAE animals, which may be attributed to the improvement of microenvironment.

The data suggests that C16 peptide may act as a protective agent by attenuating inflammatory progression and thus affecting the expression of some proinflammatory cytokines during neuroinflammatory disease.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Han, Shu& Zhang, Fan& Hu, Zhiying& Sun, Yayi& Yang, Jing& Davies, Henry…[et al.]. 2013. Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-24.
https://search.emarefa.net/detail/BIM-458924

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Han, Shu…[et al.]. Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide. Mediators of Inflammation No. 2013 (2013), pp.1-24.
https://search.emarefa.net/detail/BIM-458924

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Han, Shu& Zhang, Fan& Hu, Zhiying& Sun, Yayi& Yang, Jing& Davies, Henry…[et al.]. Dose-Dependent Anti-Inflammatory and Neuroprotective Effects of an ανβ3 Integrin-Binding Peptide. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-24.
https://search.emarefa.net/detail/BIM-458924

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-458924