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Anaplastic Large-Cell Lymphoma in a Child with Type I Diabetes and Unrecognised Coeliac Disease
المؤلفون المشاركون
Pizer, Barry
Sharp, Jemima
Kokai, George
Auth, Marcus K. H.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-03
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Screening for coeliac disease is recommended for children from certain risk groups, with implications for diagnostic procedures and dietetic management.
The risk of a malignant complication in untreated coeliac disease is not considered high in children.
We present the case of a girl with type I diabetes who developed weight loss, fatigue, and inguinal lymphadenopathy.
Four years before, when she was asymptomatic, a screening coeliac tTG test was positive, but gluten was not eliminated from her diet.
Based on clinical examination, a duodenal biopsy, and an inguinal lymph node biopsy were performed, which confirmed both coeliac disease and an anaplastic large-cell lymphoma.
HLA-typing demonstrated that she was homozygous for HLA-DQ8, which is associated with higher risk for celiac disease, more severe gluten sensitivity, and diabetes susceptibility.
She responded well to chemotherapy and has been in remission for over 4 years.
She remains on a gluten-free diet.
This is the first case reporting the association of coeliac disease, type I diabetes, and anaplastic large-cell lymphoma in childhood.
The case highlights the malignancy risk in a genetically predisposed individual, and the possible role of a perpetuated immunologic response by prolonged gluten exposure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sharp, Jemima& Pizer, Barry& Kokai, George& Auth, Marcus K. H.. 2012. Anaplastic Large-Cell Lymphoma in a Child with Type I Diabetes and Unrecognised Coeliac Disease. Case Reports in Pediatrics،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-459055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sharp, Jemima…[et al.]. Anaplastic Large-Cell Lymphoma in a Child with Type I Diabetes and Unrecognised Coeliac Disease. Case Reports in Pediatrics No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-459055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sharp, Jemima& Pizer, Barry& Kokai, George& Auth, Marcus K. H.. Anaplastic Large-Cell Lymphoma in a Child with Type I Diabetes and Unrecognised Coeliac Disease. Case Reports in Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-459055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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