Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811
المؤلفون المشاركون
Zhong, Zhi
Rehman, Hasibur
Liu, Qinlong
Harley, Russell A.
Lemasters, John J.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-22
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Pulmonary complications after liver transplantation (LT) often cause mortality.
This study investigated whether small-for-size LT increases acute pulmonary injury and whether NIM811 which improves small-for-size liver graft survival attenuates LT-associated lung injury.
Rat livers were reduced to 50% of original size, stored in UW-solution with and without NIM811 (5 μM) for 6 h, and implanted into recipients of the same or about twice the donor weight, resulting in half-size (HSG) and quarter-size grafts (QSG), respectively.
Liver injury increased and regeneration was suppressed after QSG transplantation as expected.
NIM811 blunted these alterations >75%.
Pulmonary histological alterations were minimal at 5–18 h after LT.
At 38 h, neutrophils and monocytes/macrophage infiltration, alveolar space exudation, alveolar septal thickening, oxidative/nitrosative protein adduct formation, and alveolar epithelial cell/capillary endothelial apoptosis became overt in the lungs of QSG recipients, but these alterations were mild in full-size and HSG recipients.
Liver pretreatment with NIM811 markedly decreased pulmonary injury in QSG recipients.
Hepatic TNFα and IL-1β mRNAs and pulmonary ICAM-1 expression were markedly higher after QSG transplantation, which were all decreased by NIM811.
Together, dysfunctional small-for-size grafts produce toxic cytokines, leading to lung inflammation and injury.
NIM811 decreased toxic cytokine formation, thus attenuating pulmonary injury after small-for-size LT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Qinlong& Rehman, Hasibur& Harley, Russell A.& Lemasters, John J.& Zhong, Zhi. 2012. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811. HPB Surgery،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-459087
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Qinlong…[et al.]. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811. HPB Surgery No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-459087
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Qinlong& Rehman, Hasibur& Harley, Russell A.& Lemasters, John J.& Zhong, Zhi. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-459087
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459087
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر