Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811

المؤلفون المشاركون

Zhong, Zhi
Rehman, Hasibur
Liu, Qinlong
Harley, Russell A.
Lemasters, John J.

المصدر

HPB Surgery

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-05-22

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الطب البشري

الملخص EN

Pulmonary complications after liver transplantation (LT) often cause mortality.

This study investigated whether small-for-size LT increases acute pulmonary injury and whether NIM811 which improves small-for-size liver graft survival attenuates LT-associated lung injury.

Rat livers were reduced to 50% of original size, stored in UW-solution with and without NIM811 (5 μM) for 6 h, and implanted into recipients of the same or about twice the donor weight, resulting in half-size (HSG) and quarter-size grafts (QSG), respectively.

Liver injury increased and regeneration was suppressed after QSG transplantation as expected.

NIM811 blunted these alterations >75%.

Pulmonary histological alterations were minimal at 5–18 h after LT.

At 38 h, neutrophils and monocytes/macrophage infiltration, alveolar space exudation, alveolar septal thickening, oxidative/nitrosative protein adduct formation, and alveolar epithelial cell/capillary endothelial apoptosis became overt in the lungs of QSG recipients, but these alterations were mild in full-size and HSG recipients.

Liver pretreatment with NIM811 markedly decreased pulmonary injury in QSG recipients.

Hepatic TNFα and IL-1β mRNAs and pulmonary ICAM-1 expression were markedly higher after QSG transplantation, which were all decreased by NIM811.

Together, dysfunctional small-for-size grafts produce toxic cytokines, leading to lung inflammation and injury.

NIM811 decreased toxic cytokine formation, thus attenuating pulmonary injury after small-for-size LT.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Qinlong& Rehman, Hasibur& Harley, Russell A.& Lemasters, John J.& Zhong, Zhi. 2012. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811. HPB Surgery،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-459087

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Qinlong…[et al.]. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811. HPB Surgery No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-459087

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Qinlong& Rehman, Hasibur& Harley, Russell A.& Lemasters, John J.& Zhong, Zhi. Small-for-Size Liver Transplantation Increases Pulmonary Injury in Rats : Prevention by NIM811. HPB Surgery. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-459087

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-459087