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Combinations of TLR Ligands : A Promising Approach in Cancer Immunotherapy
المؤلفون المشاركون
Klier, Ulrike
Stier, Saskia
Maletzki, Claudia
Linnebacher, Michael
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-25
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Toll-like receptors (TLRs), a family of pattern recognition receptors recognizing molecules expressed by pathogens, are typically expressed by immune cells.
However, several recent studies revealed functional TLR expression also on tumor cells.
Their expression is a two-sided coin for tumor cells.
Not only tumor-promoting effects of TLR ligands are described but also direct oncopathic and immunostimulatory effects.
To clarify TLRs’ role in colorectal cancer (CRC), we tested the impact of the TLR ligands LPS, Poly I:C, R848, and Taxol on primary human CRC cell lines (HROC40, HROC60, and HROC69) in vitro and in vivo (CT26).
Taxol, not only a potent tumor-apoptosis-inducing, but also TLR4-activating chemotherapeutic compound, inhibited growth and viability of all cell lines, whereas the remaining TLR ligands had only marginal effects (R848 > LPS > Poly I:C).
Combinations of the substances here did not improve the results, whereas antitumoral effects were dramatically boosted when human lymphocytes were added.
Here, combining the TLR ligands often diminished antitumoral effects.
In vivo, best tumor growth control was achieved by the combination of Taxol and R848.
However, when combined with LPS, Taxol accelerated tumor growth.
These data generally prove the potential of TLR ligands to control tumor growth and activate immune cells, but they also demonstrate the importance of choosing the right combinations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Stier, Saskia& Maletzki, Claudia& Klier, Ulrike& Linnebacher, Michael. 2013. Combinations of TLR Ligands : A Promising Approach in Cancer Immunotherapy. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Stier, Saskia…[et al.]. Combinations of TLR Ligands : A Promising Approach in Cancer Immunotherapy. Clinical and Developmental Immunology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-459173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Stier, Saskia& Maletzki, Claudia& Klier, Ulrike& Linnebacher, Michael. Combinations of TLR Ligands : A Promising Approach in Cancer Immunotherapy. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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