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The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis
المؤلفون المشاركون
Castelli-Haley, J.
Tarrants, M.
Oleen-Burkey, M.
Lage, M. J.
المصدر
Multiple Sclerosis International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-02
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Examine the impact of comorbid depression on adherence to disease-modifying therapy (DMT) for multiple sclerosis (MS).
Methods.
A retrospective database was used to identify patients with MS treated with a DMT.
Patients with MS and comorbid depression were matched to patients with MS only.
Adherence to DMT was proxied by the medication possession ratio (MPR) and multivariate regressions were used to examine the association between comorbid depression and adherence to DMT.
Results.
Patients with comorbid depression had a 10 point lower MPR (P<0.01) and were less likely to achieve a MPR of at least 80% (odds ratio (OR)=0.55; 95% confidence interval (CI) 0.42–0.74) than those without depression.
While treatment with an antidepressant generally had no significant impact on the likelihood of achieving an MPR threshold of 80% (OR=1.32; 95% CI 0.50–3.48), adherence to antidepressant therapy guidelines were associated with improved adherence to DMT therapy.
Conclusions.
MS patients with comorbid depression were approximately half as likely to be adherent to their DMT relative to patients with MS without depression.
Although treatment with antidepressant therapy generally did not improve the likelihood of adherence, treatment with antidepressants for at least 6 months was associated with better adherence to DMT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tarrants, M.& Oleen-Burkey, M.& Castelli-Haley, J.& Lage, M. J.. 2011. The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459181
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tarrants, M.…[et al.]. The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis. Multiple Sclerosis International No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-459181
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tarrants, M.& Oleen-Burkey, M.& Castelli-Haley, J.& Lage, M. J.. The Impact of Comorbid Depression on Adherence to Therapy for Multiple Sclerosis. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-459181
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459181
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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