Randomized Controlled Trial of Etodolac versus Combination of Etodolac and Eperisone in Patients of Knee Osteoarthritis
المؤلفون المشاركون
Kaur, Navjot
Gupta, Avinash Chander
Singh, Harinder
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To compare the efficacy and tolerability of etodolac versus etodolac in combination with eperisone in patients of Osteoarthritis knee.
Patients and Methods.
A prospective, randomized, open label, parallel group, comparative study was conducted in 60 patients of knee OA over a period of 2 months.
Thirty patients received etodolac 600 mg once daily and 30 patients received eperisone 50 mg thrice daily in addition to etodolac 600 mg once daily for 8 weeks.
Efficacy assessment was done on the basis of improvement in mean scores of spontaneous pain on Visual analog scale (VAS), pain on movement, functional capacity, joint tenderness, swelling, erythema on Likert scale, and patient's overall arthritic condition on a five-point investigator scale at the end of study period as compared with the baseline scores.
Assessment of tolerability was done by recording the occurrence of adverse events.
Data was analyzed using Chi square test and students t-test.
Results.
All the enrolled patients completed the study and were compliant to the treatment regimens that they were allocated to.
Both the treatment groups showed a statistically significant improvement in all the efficacy parameters at the end of 8 weeks as compared to baseline (P<0.05) with no statistically significant difference between the groups.
Adverse events were few and mild in nature.
Conclusion.
Combination of etodolac and eperisone is as effective as etodolac alone in patients of OA knee.
Thus, it is concluded that additional use of muscle relaxant has no adjuvant value in patients of OA knee and is not recommended.
The study is registered with the Clinical Trial Registry of India vide registration number CTRI/2013/03/003442.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaur, Navjot& Singh, Harinder& Gupta, Avinash Chander. 2013. Randomized Controlled Trial of Etodolac versus Combination of Etodolac and Eperisone in Patients of Knee Osteoarthritis. Pain Research and Treatment،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459400
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaur, Navjot…[et al.]. Randomized Controlled Trial of Etodolac versus Combination of Etodolac and Eperisone in Patients of Knee Osteoarthritis. Pain Research and Treatment No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-459400
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaur, Navjot& Singh, Harinder& Gupta, Avinash Chander. Randomized Controlled Trial of Etodolac versus Combination of Etodolac and Eperisone in Patients of Knee Osteoarthritis. Pain Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459400
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459400
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر