Plasma Drug Level Validates Self-Reported Adherence but Predicts Limited Specificity for Nonadherence to Antiretroviral Therapy
المؤلفون المشاركون
Baveewo, Steven
Musoke, David
Kayiwa, Joshua
Waako, Paul
Obua, Celestino
Ntale, Muhammad
Balikuddembe, Robert
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
علم الصيدلة
الملخص EN
Introduction.
Adherence to antiretroviral therapy (ART) in low-income countries is mainly assessed by self-reported adherence (S-RA) without drug level determination.
Nonadherence is an important factor in the emergence of resistance to ART, presenting a need for drug level determination.
Objective.
We set out to establish the relationship between plasma stavudine levels and S-RA and validate S-RA against the actual plasma drug concentrations.
Methods.
A cross-sectional investigation involving 234 patients in Uganda.
Stavudine plasma levels were determined using high-performance liquid chromatography.
We compared categories of plasma levels of stavudine with S-RA using multivariable logistic regression models.
Results.
Overall, 194/234 patients had S-RA ≥ 95% (good adherence) and 166/234 had stavudine plasma concentrations ≥ 36 nmol/L (therapeuticconcentration).
Patients with good S-RA were eight times more likely to have stavudine levels within therapeutic concentration (Adjusted Odds Ratio: 7.7, 95% Confidence Interval: 3.5–7.0).
However, of the 194 patients with good S-RA, 21.7% had below therapeutic concentrations.
S-RA had high sensitivity for adherence (91.6%), but limited specificity for intrinsic poor adherence (38.2%).
Conclusions.
S-RA is a good tool for assessing adherence, but has low specificity in detecting nonadherence, which has implications for emergence of resistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Balikuddembe, Robert& Kayiwa, Joshua& Musoke, David& Ntale, Muhammad& Baveewo, Steven& Waako, Paul…[et al.]. 2012. Plasma Drug Level Validates Self-Reported Adherence but Predicts Limited Specificity for Nonadherence to Antiretroviral Therapy. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459512
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Balikuddembe, Robert…[et al.]. Plasma Drug Level Validates Self-Reported Adherence but Predicts Limited Specificity for Nonadherence to Antiretroviral Therapy. ISRN Pharmacology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-459512
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Balikuddembe, Robert& Kayiwa, Joshua& Musoke, David& Ntale, Muhammad& Baveewo, Steven& Waako, Paul…[et al.]. Plasma Drug Level Validates Self-Reported Adherence but Predicts Limited Specificity for Nonadherence to Antiretroviral Therapy. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-459512
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459512
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر