The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats
المؤلفون المشاركون
Dang, Ningning
Jiang, Qiang
Wang, Lulu
Lu, Yong
Huang, Xianping
Duan, Guanglan
Pang, Shuguang
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effect of simvastatin on glucose homeostasis in streptozotocin induced type 2 diabetic rats.
Methods.
Forty male Wistar rats were randomly divided into four groups.
Normal control rats were fed with standard diet, others were fed with high-fat diet.
Diabetic rats were induced by a single intraperitoneal injection of STZ.
The simvastatin intervention rats were fed with simvastatin during the experiment process, and the simvastatin treatment rats were fed with simvastatin after diabetes rats were induced.
We measured body weight, fasting plasma glucose, cholesterol, high-density lipoprotein cholesterol, and triglyceride after an overnight fast.
Results.
The FPG was higher in diabetic rats when compared to normal control ones; the simvastatin intervention rats had a higher FPG compared to the diabetic rats and were more easily be induced to diabetes at the end of 4 weeks, FPG level of simvastatin treatment rats was increased compared with diabetic model rats after 12 weeks.
Conclusion.
These data indicate that simvastatin intervention rats may cause hyperglycemia by impairing the function of islet β cells and have an adverse effect on glucose homeostasis, especially on FPG level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lulu& Duan, Guanglan& Lu, Yong& Pang, Shuguang& Huang, Xianping& Jiang, Qiang…[et al.]. 2013. The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459514
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lulu…[et al.]. The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats. Journal of Diabetes Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-459514
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lulu& Duan, Guanglan& Lu, Yong& Pang, Shuguang& Huang, Xianping& Jiang, Qiang…[et al.]. The Effect of Simvastatin on Glucose Homeostasis in Streptozotocin Induced Type 2 Diabetic Rats. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-459514
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459514
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر