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Correlation of Plasma MMP-1 and TIMP-1 Levels and the Colonic Mucosa Expressions in Patients with Ulcerative Colitis
المؤلفون المشاركون
Zhang, Ke
Tan, Xiao-Yan
Wang, Ying-De
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-11-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Both plasma and mucosal levels of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) have been shown to be independently correlated with ulcerative colitis (UC), but their relationship with each other and to disease severity remains unclear.
This study aims to evaluate the relationship between colonic mucosal and plasma levels of MMP-1 and TIMP-1 with each other and with the severity of ulcerative colitis (UC).
Methods.
Colonic mucosal lesions and venous blood samples were collected from 30 patients with UC and 15 normal subjects.
Real-time reverse transcription-PCR and immunohistochemistry were used to determine colonic mucosal MMP-1 and TIMP-1 expression; ELISA was used to measure plasma levels of MMP-1 and TIMP-1.
Results.
Expression of colonic mucosal and plasma MMP-1 and TIMP-1 in patients with UC was significantly higher than that of controls (P<.05), and was positively correlated with disease severity (P<.05).
Plasma MMP-1 and TIMP-1 levels were well correlated with their corresponding expression in colonic mucosa (P<.05, r= 0.805 and 0.908).
Conclusion.
Plasma MMP-1 and TIMP-1 levels reflect their colonic mucosal expression to some extent in patients with UC.
Plasma MMP-1 and TIMP-1, in particular, demonstrate the potential to become biomarkers to clinically diagnose UC, predict its severity, and guide further therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ying-De& Tan, Xiao-Yan& Zhang, Ke. 2009. Correlation of Plasma MMP-1 and TIMP-1 Levels and the Colonic Mucosa Expressions in Patients with Ulcerative Colitis. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-459522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ying-De…[et al.]. Correlation of Plasma MMP-1 and TIMP-1 Levels and the Colonic Mucosa Expressions in Patients with Ulcerative Colitis. Mediators of Inflammation No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-459522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ying-De& Tan, Xiao-Yan& Zhang, Ke. Correlation of Plasma MMP-1 and TIMP-1 Levels and the Colonic Mucosa Expressions in Patients with Ulcerative Colitis. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-459522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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