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Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model
المؤلفون المشاركون
Lin, Wan-Teng
Huang, Chi-Chang
Chiang, Wen-Dee
Huang, Chih-Yang
Huang, Wen-Ching
Hsu, Mei-Chich
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-16
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study investigates whether a 12-week swimming exercise training can prevent liver damage or senescence associated biomarkers in an experimental aging model in rats.
Twenty-three male Sprague-Dawley rats were divided into four groups: vehicle treatment with sedentary control (C, n=6), aging induction with sedentary (A, n=6), vehicle treatment with swimming exercise (SW, n=5), and aging induction with swimming exercise (A + SW, n=6).
Rats in groups A and AS received intraperitoneal d-galactose injections (150 mg/kg/day) for 12 weeks to induce aging.
Rats in groups SW and A + SW were subjected to swimming exercise training for 12 weeks.
Body weight, liver weight, epididymal fat mass, blood biochemistry, and liver pathology were performed at the end of the experiment.
Hepatic senescence protein markers such as β-galactosidase, p53, and p21, as well as the inflammatory mediator, IL-6, were examined.
The d-galactose-treated rats exhibited increases in AST and γ-GT plasma levels and β-galactosidase protein expression compared to the control group.
Swimming exercise significantly reduced BW, epididymal fat mass, γ-GT activity, and p53, p21, and IL-6 protein levels compared to the aging group.
These results suggest that a 12-week swimming exercise program suppresses senescence markers and downregulates inflammatory mediator in the liver tissues of d-galactose-induced aging rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Chi-Chang& Chiang, Wen-Dee& Huang, Wen-Ching& Huang, Chih-Yang& Hsu, Mei-Chich& Lin, Wan-Teng. 2013. Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-459560
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Chi-Chang…[et al.]. Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-459560
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Chi-Chang& Chiang, Wen-Dee& Huang, Wen-Ching& Huang, Chih-Yang& Hsu, Mei-Chich& Lin, Wan-Teng. Hepatoprotective Effects of Swimming Exercise against D-Galactose-Induced Senescence Rat Model. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-459560
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459560
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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