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Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va
المؤلفون المشاركون
Salerno, Verônica P.
Terra, Rodrigo
Azevedo, Elisama
Dutra, Patrícia Maria Lourenço
Castro Lima, Ana Karina
Oliveira, Leandro Teixeira
المصدر
Journal of Parasitology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-27
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Leishmaniasis is a neglected tropical disease with no effective vaccines.
Actin, microtubules and the actin-based molecular motor myosin Va were investigated for their involvement in Leishmania braziliensis macrophage interactions.
Results showed a decrease in the association index when macrophages were without F-actin or microtubules regardless of the activation state of the macrophage.
In the absence of F-actin, the production of NO in non-activated cells increased, while in activated cells, the production of NO was reduced independent of parasites.
The opposite effect of an increased NO production was observed in the absence of microtubules.
In activated cells, the loss of cytoskeletal components inhibited the release of IL-10 during parasite interactions.
The production of IL-10 also decreased in the absence of actin or microtubules in non-activated macrophages.
Only the disruption of actin altered the production of TNF-α in activated macrophages.
The expression of myosin Va tail resulted in an acute decrease in the association index between transfected macrophages and L.
braziliensis promastigotes.
These data reveal the importance of F-actin, microtubules, and myosin-Va suggesting that modulation of the cytoskeleton may be a mechanism used by L.
braziliensis to overcome the natural responses of macrophages to establish infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azevedo, Elisama& Oliveira, Leandro Teixeira& Castro Lima, Ana Karina& Terra, Rodrigo& Dutra, Patrícia Maria Lourenço& Salerno, Verônica P.. 2012. Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-459561
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azevedo, Elisama…[et al.]. Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va. Journal of Parasitology Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-459561
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azevedo, Elisama& Oliveira, Leandro Teixeira& Castro Lima, Ana Karina& Terra, Rodrigo& Dutra, Patrícia Maria Lourenço& Salerno, Verônica P.. Interactions between Leishmania braziliensis and Macrophages Are Dependent on the Cytoskeleton and Myosin Va. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-459561
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459561
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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