Indoleamine 2,3-Dioxygenase : Expressing Cells in Inflammatory Bowel Disease—A Cross-Sectional Study
المؤلفون المشاركون
Fonseca-Camarillo, Gabriela
Lima, Guadalupe
Yamamoto-Furusho, Jesús K.
Furuzawa-Carballeda, Janette
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-27
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Aim.
To characterise and enumerate IDO+ cells, Tregs, and T cell subsets in patients with ulcerative colitis (UC) and Crohn’s disease (CD) with regard to their clinical activity.
Methods.
Ten active UC (aUC), 10 inactive UC (iUC), 6 aCD, and 8 iCD patients and 10 healthy individuals were included in the study.
Circulating Foxp3-, IDO-, IL-17A-, IL-4-, IFN-γ-, and IL-10-expressing CD4+ T cells were quantitated by flow cytometry.
Interleukin-17-expressing cells, CD25+/Foxp3+ Tregs, and CD123+/IDO+ plasmacytoid dendritic cells were evaluated in intestinal biopsies from 10 aUC, 6 aCD, and 10 noninflamed tissues.
Results.
All CD4+ T subsets were increased in aIBD patients compared with healthy donors.
Meanwhile, frequency of CD8α+/CD16+/IDO+, CD8α+/CD56+/IDO+, CD8α+/CD80+/IDO+, CD8α+/CD123+/IDO+ large granular nonlymphoid cells, and CCR6+/CD123+/IDO+ plasmacytoid dendritic cells was higher in aIBD patients versus healthy donors or iIBD patients.
Tissue IL-17A+ cells were present in higher amounts in aIBD versus noninflamed controls.
IDO- and Foxp3-expressing cells were increased in aUC versus aCD patients and noninflamed tissues.
Conclusions.
The findings represent an original work in Mexican Mestizo patients with IBD.
It shows that Tregs and IDO-expressing cells are increased with regard to disease activity.
These cells could significantly shape inflammatory bowel disease pathophysiology, severity, and tolerance loss.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Furuzawa-Carballeda, Janette& Fonseca-Camarillo, Gabriela& Lima, Guadalupe& Yamamoto-Furusho, Jesús K.. 2013. Indoleamine 2,3-Dioxygenase : Expressing Cells in Inflammatory Bowel Disease—A Cross-Sectional Study. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459693
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Furuzawa-Carballeda, Janette…[et al.]. Indoleamine 2,3-Dioxygenase : Expressing Cells in Inflammatory Bowel Disease—A Cross-Sectional Study. Clinical and Developmental Immunology No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-459693
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Furuzawa-Carballeda, Janette& Fonseca-Camarillo, Gabriela& Lima, Guadalupe& Yamamoto-Furusho, Jesús K.. Indoleamine 2,3-Dioxygenase : Expressing Cells in Inflammatory Bowel Disease—A Cross-Sectional Study. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-459693
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459693
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر