Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques
المؤلفون المشاركون
Zinellu, Angelo
Piredda, Franco
Bacciu, Pietro Paolo
Formato, Marilena
Cigliano, Antonio
Zinellu, Elisabetta
Carru, Ciriaco
Spirito, Rita
Guarino, Anna
Pisanu, Salvatore
Lepedda, Antonio Junior
المصدر
Biochemistry Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Several studies have evidenced variations in plasma glycosaminoglycans content in physiological and pathological conditions.
In normal human plasma GAGs are present mainly as undersulfated chondroitin sulfate (CS).
The aim of the present study was to evaluate possible correlations between plasma CS level/structure and the presence/typology of carotid atherosclerotic lesion.
Plasma CS was purified from 46 control subjects and 47 patients undergoing carotid endarterectomy showing either a soft or a hard plaque.
The concentration and structural characteristics of plasma CS were assessed by capillary electrophoresis of constituent unsaturated fluorophore-labeled disaccharides.
Results showed that the concentration of total CS isomers was increased by 21.4% (P<0.01) in plasma of patients, due to a significant increase of undersulfated CS.
Consequently, in patients the plasma CS charge density was significantly reduced with respect to that of controls.
After sorting for plaque typology, we found that patients with soft plaques and those with hard ones differently contribute to the observed changes.
In plasma from patients with soft plaques, the increase in CS content was not associated with modifications of its sulfation pattern.
On the contrary, the presence of hard plaques was associated with CS sulfation pattern modifications in presence of quite normal total CS isomers levels.
These results suggest that the plasma CS content and structure could be related to the presence and the typology of atherosclerotic plaque and could provide a useful diagnostic tool, as well as information on the molecular mechanisms responsible for plaque instability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zinellu, Elisabetta& Lepedda, Antonio Junior& Cigliano, Antonio& Pisanu, Salvatore& Zinellu, Angelo& Carru, Ciriaco…[et al.]. 2011. Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zinellu, Elisabetta…[et al.]. Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques. Biochemistry Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-459986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zinellu, Elisabetta& Lepedda, Antonio Junior& Cigliano, Antonio& Pisanu, Salvatore& Zinellu, Angelo& Carru, Ciriaco…[et al.]. Association between Human Plasma Chondroitin Sulfate Isomers and Carotid Atherosclerotic Plaques. Biochemistry Research International. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-459986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-459986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر