The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A
المؤلفون المشاركون
de Beer, Frederick C.
Webb, Nancy R.
de Beer, Maria C.
Ji, Ailing
Wroblewski, Joanne M.
Noffsinger, Victoria P.
van der Westhuyzen, Deneys R.
Meyer, Jason M.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Studies suggest that inflammation impairs reverse cholesterol transport (RCT).
We investigated whether serum amyloid A (SAA) contributes to this impairment using an established macrophage-to-feces RCT model.
Wild-type (WT) mice and mice deficient in SAA1.1 and SAA2.1 (SAAKO) were injected intraperitoneally with 3H-cholesterol-labeled J774 macrophages 4 hr after administration of LPS or buffered saline.
3H-cholesterol in plasma 4 hr after macrophage injection was significantly reduced in both WT and SAAKO mice injected with LPS, but this was not associated with a reduced capacity of serum from LPS-injected mice to promote macrophage cholesterol efflux in vitro.
Hepatic accumulation of 3H-cholesterol was unaltered in either WT or SAAKO mice by LPS treatment.
Radioactivity present in bile and feces of LPS-injected WT mice 24 hr after macrophage injection was reduced by 36% (P<0.05) and 80% (P<0.001), respectively.
In contrast, in SAAKO mice, LPS did not significantly reduce macrophage-derived 3H-cholesterol in bile, and fecal excretion was reduced by only 45% (P<0.05).
Injection of cholesterol-loaded allogeneic J774 cells, but not syngeneic bone-marrow-derived macrophages, transiently induced SAA in C57BL/6 mice.
Our study confirms reports that acute inflammation impairs steps in the RCT pathway and establishes that SAA plays only a minor role in this impairment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Beer, Maria C.& Wroblewski, Joanne M.& Noffsinger, Victoria P.& Ji, Ailing& Meyer, Jason M.& van der Westhuyzen, Deneys R.…[et al.]. 2013. The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A. Journal of Lipids،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460190
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Beer, Maria C.…[et al.]. The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A. Journal of Lipids No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-460190
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Beer, Maria C.& Wroblewski, Joanne M.& Noffsinger, Victoria P.& Ji, Ailing& Meyer, Jason M.& van der Westhuyzen, Deneys R.…[et al.]. The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A. Journal of Lipids. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-460190
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460190
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر