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Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model
المؤلفون المشاركون
Ashrafi, Farzaneh
Mansouri, Azam
Haghighi, Maryam
Talebi, Ardeshir
Nasri, Hamid
Pezeshki, Zahra
Eshraghi-Jazi, Fatemeh
Nematbakhsh, Mehdi
Safari, Tahereh
المصدر
International Journal of Nephrology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The nephroprotective effect of vitamins E and C or losartan against cisplatin (CP)- induced nephrotoxicity when they are accompanied by estrogen was investigated.
Methods.
The ovariectomized rats received estradiol valerate for two weeks.
At the end of the first week, a single dose of CP (7 mg/kg, IP) was also administered, and they received placebo (group 1), vitamin E (group 2), vitamin C (group 3), or losartan (group 4) every day during the second week, and they were compared with another three control groups.
Results.
CP alone increased the serum levels of blood urea nitrogen (BUN), creatinine (Cr), and kidney tissue damage score (KTDS), significantly (P<0.05), however at the presence of estradiol and CP, vitamin C, vitamin E, or losartan not only did not decrease these parameters, but also increased them significantly (P<0.05).
The serum level of superoxidase dismutase (SOD) was reduced by CP (P<0.05), but it was increased when estradiol or estradiol plus vitamin C or losartan were added (P<0.05).
Conclusion.
The particular pharmacological dose of estrogen used in this study abolish the nephroprotective effects vitamins C and E or losartan against CP-induced nephrotoxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nematbakhsh, Mehdi& Pezeshki, Zahra& Eshraghi-Jazi, Fatemeh& Ashrafi, Farzaneh& Nasri, Hamid& Talebi, Ardeshir…[et al.]. 2012. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nematbakhsh, Mehdi…[et al.]. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model. International Journal of Nephrology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-460325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nematbakhsh, Mehdi& Pezeshki, Zahra& Eshraghi-Jazi, Fatemeh& Ashrafi, Farzaneh& Nasri, Hamid& Talebi, Ardeshir…[et al.]. Vitamin E, Vitamin C, or Losartan Is Not Nephroprotectant against Cisplatin-Induced Nephrotoxicity in Presence of Estrogen in Ovariectomized Rat Model. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-460325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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