Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia?
المؤلفون المشاركون
Digiesi, Giovanna
Molica, Stefano
Todoerti, Katia
Ribatti, Domenico
Morabito, Fortunato
Battaglia, Caterina
Neri, Antonino
Vacca, Angelo
Mirabelli, Rosanna
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-08-27
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Angiogenesis is involved in the pathogenesis of B-cell chronic lymphocytic leukemia (CLL), and high microvascular density has been found in CLL to be associated with a poor prognosis.
In this study, we assessed serum levels of adiponectin in 69 patients with Binet stage A B-CLL, and these values were retrospectively correlated with bone marrow (BM) microvessel area and serum levels of vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), angiogenin, PECAM-1 (CD31), matrix metalloproteinase-9 (MMP-9), interleukin-8 (IL-8), syndecan-1, and the percentage of CD38+ or ZAP-70+ CLL cells.
The positive correlation between serum levels of adiponectin and VEGF (P=.03) does not translate into an increase of the extent of BM angiogenesis (P=.404), FGF-2 (P=.348), angiogenin (P=.402), and CD31 (P=.248) serum concentrations.
Accordingly, IL-8 (P=.175), syndecan-1 (P=.06), and MMP-9 (P=.144) circulating levels were not likely to reflect adiponectin concentration.
Furthermore, patients with higher levels of adiponectin had a more favorable biological profile as defined by a lower number of both CD38− (r=−0.294; P=.02) and ZAP-70+ (r=−0.285; P=.04).
Finally, we evaluated the presence of adiponectin in B-CLL cells at gene expression level.
RMA intensity values for adiponectin gene transcript denote a homogeneous low expression in B-CLL cells, whereas VEGF transcript was highly expressed with a degree of interpatient variability.
Overall, these data seem to indicate that adiponectin could be involved as an antiangiogenic factor in B-CLL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Molica, Stefano& Digiesi, Giovanna& Vacca, Angelo& Mirabelli, Rosanna& Todoerti, Katia& Battaglia, Caterina…[et al.]. 2009. Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia?. Advances in Hematology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-460618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Molica, Stefano…[et al.]. Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia?. Advances in Hematology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-460618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Molica, Stefano& Digiesi, Giovanna& Vacca, Angelo& Mirabelli, Rosanna& Todoerti, Katia& Battaglia, Caterina…[et al.]. Does Adiponectin Act as an Antiangiogenic Factor in B-Cell Chronic Lymphocytic Leukemia?. Advances in Hematology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-460618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر