Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis : A Two-Year Pilot Study
المؤلفون المشاركون
Forsblad-d'Elia, Helena
Bremell, Tomas
Pullerits, Rille
Mörck, Boel
Geijer, Mats
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The rationale of the study was to evaluate the efficacy of infliximab (IFX) treatment in patients with ankylosing spondylitis (AS) and to determine whether IFX dose reduction and interval extension sustains the treatment effect.
Nineteen patients were included and treated with IFX 5 mg/kg every 6 weeks for 56 weeks.
All patients concomitantly received MTX with median dose 7.5 mg/weekly.
During the second year, the IFX dose was reduced to 3 mg/kg every 8 weeks.
Eighteen patients completed the 1-year and 15 patients the 2-year trial.
The ≥50% improvement at week 16 from baseline of BASDAI was achieved in 16/19 (84%) patients.
Significant reductions in BASDAI, BASFI, and BASMI scores, decrease in ESR and CRP, and improvement in SF-36 were observed at weeks 16 and 56.
The MRI-defined inflammatory changes in the sacroiliac joints disappeared in 10/15 patients (67%) already at 16 weeks.
IFX treatment effect was sustained throughout the second year after IFX dose reduction and interval extension.
We conclude that IFX treatment is effective in well-established active AS and a dose reduction sustains the treatment effect.
These observations are of clinical importance and open the opportunity to reduce the drug costs.
This trial is registered with ClinicalTrials.gov NCT01850121.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mörck, Boel& Pullerits, Rille& Geijer, Mats& Bremell, Tomas& Forsblad-d'Elia, Helena. 2013. Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis : A Two-Year Pilot Study. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-460706
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mörck, Boel…[et al.]. Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis : A Two-Year Pilot Study. Mediators of Inflammation No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-460706
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mörck, Boel& Pullerits, Rille& Geijer, Mats& Bremell, Tomas& Forsblad-d'Elia, Helena. Infliximab Dose Reduction Sustains the Clinical Treatment Effect in Active HLAB27 Positive Ankylosing Spondylitis : A Two-Year Pilot Study. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-460706
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460706
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر