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(-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts : Suppression of SAPKJNK
المؤلفون المشاركون
Matsushima-Nishiwaki, Rie
Adachi, Seiji
Takai, Shinji
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-01-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively plays a part in the platelet-derived growth factor-BB- (PDGF-BB-) stimulated synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells while Akt and p70 S6 kinase negatively regulates the synthesis.
In the present study, we investigated whether (-)-epigallocatechin gallate (EGCG), one of the major green tea flavonoids, affects the synthesis of IL-6 in these cells and the mechanism.
EGCG significantly reduced the IL-6 synthesis and IL-6 mRNA expression stimulated by PDGF-BB, EGCG reduced the PDGF-BB-stimulated IL-6 synthesis also in primary-cultured osteoblasts.
EGCG had no effect on the levels of osteocalcin and osteoprotegerin in MC3T3-E1 cells.
The PDGF-BB-induced autophosphorylation of PDGF receptor β was not suppressed by EGCG.
The PDGF-BB-induced phosphorylation of p44/p42 MAP kinase and p38 MAP kinase was not affected by EGCG.
On the other hand, EGCG markedly suppressed the PDGF-BB-induced phosphorylation of SAPK/JNK.
Finally, the PDGF-BB-induced phosphorylation of Akt and p70 S6 kinase was not affected by EGCG.
These results strongly suggest that EGCG inhibits the PDGF-BB-stimulated synthesis of IL-6 via suppression of SAPK/JNK pathway in osteoblasts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takai, Shinji& Matsushima-Nishiwaki, Rie& Adachi, Seiji. 2009. (-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts : Suppression of SAPKJNK. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-460909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takai, Shinji…[et al.]. (-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts : Suppression of SAPKJNK. Mediators of Inflammation No. 2008 (2008), pp.1-8.
https://search.emarefa.net/detail/BIM-460909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takai, Shinji& Matsushima-Nishiwaki, Rie& Adachi, Seiji. (-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts : Suppression of SAPKJNK. Mediators of Inflammation. 2009. Vol. 2008, no. 2008, pp.1-8.
https://search.emarefa.net/detail/BIM-460909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-460909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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