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Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia : First-in-Human, Proof-of-Concept Trial
المؤلفون المشاركون
Ferrer, Annia
Torrens, Isis
Fanjull, Sonia
Ramos, Thelvia
Gonzalez, Leonardo
Baladron, Idania
Borbon, Zaida
Granadillo, Milaid
Solares, Ana M.
Batte, Aileen
Ale, Mayte
Castillo, Dagnelia
Lopez-Saura, Pedro
Valenzuela, Carmen
Cintado, Alberto
Fernandez de Cossio, Maria E.
Esmir, Julio
المصدر
ISRN Obstetrics and Gynecology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
CIGB-228 is a novel therapeutic vaccine consisting of HLA-restricted HPV16 E7 epitope adjuvated with VSSP.
This trial was designed to evaluate the toxicity, safety, immunogenicity, HPV clearance, and lesion regression.
Methods.
Seven women were entered.
All were HLA-A2 positive, had biopsy-proven high-grade CIN, histologically positive for HPV16, and beared persistent postbiopsy lesions visible by digital colposcopy.
HLA-A2 women with biopsy-proven high-grade CIN, HPV16-positive, and beared persistent postbiopsy lesions visible by digital colposcopy were vaccinated.
One weekly injections of CIGB-228 vaccine was given for four weeks.
Then, loop electrosurgical excision procedure (LEEP) of the transformation zone was performed.
Study subjects were followed for 1 year after LEEP.
Results.
No toxicity beyond grade 1 was observed during and after the four vaccinations.
Five of seven women had complete and partial regression.
Cellular immune response was seen in all patients.
HPV was cleared in three of the patients with complete response.
Conclusion.
CIGB-228 vaccination was well tolerated and capable to induce IFNγ-associated T-cell response in women with high-grade CIN.
In several patients, lesion regression and HPV clearance were observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Solares, Ana M.& Baladron, Idania& Ramos, Thelvia& Valenzuela, Carmen& Borbon, Zaida& Fanjull, Sonia…[et al.]. 2011. Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia : First-in-Human, Proof-of-Concept Trial. ISRN Obstetrics and Gynecology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-461000
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Solares, Ana M.…[et al.]. Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia : First-in-Human, Proof-of-Concept Trial. ISRN Obstetrics and Gynecology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-461000
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Solares, Ana M.& Baladron, Idania& Ramos, Thelvia& Valenzuela, Carmen& Borbon, Zaida& Fanjull, Sonia…[et al.]. Safety and Immunogenicity of a Human Papillomavirus Peptide Vaccine (CIGB-228) in Women with High-Grade Cervical Intraepithelial Neoplasia : First-in-Human, Proof-of-Concept Trial. ISRN Obstetrics and Gynecology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-461000
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461000
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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